比较吡柔比星和丝裂霉素于膀胱灌注对预防浅表性膀胱癌术后复发的疗效与安全性  

Comparison the effect and safety of pirarubicin and mitomycin by bladder instillation for preventing postoperative recurrence on the superficial bladder cancer

作　　者：陈柏康[1] 高莉萍[1] 俞洪元[1] 蒋武斌[1] 吴松江[1] 卢子文[1] 柯莽[1] 丁崇标[1] 

机构地区：[1]浙江省台州医院泌尿外科,浙江台州临海317000

出　　处：《中国临床药理学杂志》2010年第10期723-725,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的比较吡柔比星(蒽环类抗肿瘤药)与丝裂霉素(抗肿瘤药)膀胱灌注对预防浅表性膀胱移行细胞癌术后复发的效疗与安全性。方法将83例浅表性膀胱肿瘤术后的患者,随机分成2组,分别用吡柔比星和丝裂霉素作膀胱灌注化疗,定期行膀胱镜及血常规、肝肾功能检查,观察疗效与副作用。结果吡柔比星组1例(2.3%)复发,丝裂霉素组6例(14.6%)复发,复发率吡柔比星组明显低于丝裂霉素组(P<0.05);膀胱刺激症,吡柔比星组6例(14.3%),丝裂霉素组未出现。结论与丝裂霉素相比,吡柔比星具有膀胱内保留时间短、疗程短、疗效高及门诊治疗方便等优点。Objective To compare the effect and safety of pirarubicin （THP） and mitomycin （MMC） by bladder instillation after transurethral resection or partial cystectomy of superficial bladder transient cell carcinoma. Methods Eighty - three patients of superficial bladder cancer after transurethral resection or partial cystectomy were randomly divided into two groups to receive intravesical instillation of THP （42 cases ） or MMC （41cases）, respectively. Periodical cystoscopy and blood examination were performed in all. Results The tumor recurrent rate in THP group and MMC group were （2.3%） and （ 14.6% ）, respectively. The tumor recurrent rate of THP group differed significantly from the MMC group （P 〈 0. 05 ）. The adverce drug reaction of the two groups, THP group was higher than MMC group in the lower urinary tract symptoms. Conclusion Intravesical administration of THP after operation was more effective than MMC, which had the merit of short - duration, shorter period of treatmeat, and more convenience for preventing tumor recurrence.

关 键 词：膀胱肿瘤 吡柔比星 丝裂霉素 膀胱灌注 

分 类 号：R737.14[医药卫生—肿瘤] R979.1[医药卫生—临床医学]