甘草黄酮对2型糖尿病大鼠高血糖、高血脂的抑制作用  

Suppressive effect of licorice flavonoids on hyperglycemia and hyperlipidemia in type 2 diabetic rats

作　　者：赵海燕[1] 王勇[1] 马永平[1] 王奕[1] 

机构地区：[1]北方民族大学生物科学与工程学院,宁夏银川750021

出　　处：《中国现代医学杂志》2010年第17期2573-2578,共6页China Journal of Modern Medicine

基　　金：国家教育部留学回国人员科研启动基金;宁夏高等学校科研项目(No:2009JY003)

摘　　要：目的研究甘草黄酮(LF)对2型糖尿病大鼠血糖、血脂等生化指标的影响。方法将实验大鼠分为正常对照组(Control)、正常给药组(CLF)、模型组(DM)、高剂量给药组(HLF)、低剂量给药组(LLF)、预防对照组[100mg、300mg/(kg·d)](PC)和预防给药组(PLF)。分别以LF或溶剂(1,2-丙二醇)灌胃。检测实验大鼠的空腹血糖、血脂等生化指标及肝体比、肾体比和脂体比。结果高剂量甘草黄酮[300mg/(kg·d)]显著降低了糖尿病大鼠的FBG、TG、TC、LDL-C、FFA、TNF-α、Leptin、肝体比和肾体比,并显著提高了糖尿病大鼠的T-AOC、ISI和脂体比。预防给药[300mg/(kg·d)]显著抑制了由高脂高糖饲料喂养结合小剂量STZ(35mg/kg)注射引发的FBG、TG、TC、LDL-C和肝体比水平的升高及脂体比的下降,并显著提高了实验大鼠的T-AOC。结论甘草黄酮对2型糖尿病大鼠血糖的升高和脂代谢紊乱具有显著的抑制作用。ObjectiveTo study the effect of licorice flavonoids（LF） on fasting blood glucose（FBG）,lipids and other biochemical indicators in type 2 diabetic rats.MethodsThe experimental rats were divided into model group（DM）,high-dose treatment group（HLF）,low-dose treatment groups（LLF）,preventive control group[100 mg,300 mg/（kg·d）]（PC） and preventive treatment group（PLF）.Other 20 normal rats were divided into control group and control treatment group（CLF）.Rats in different groups were orally administered with LF [100 mg or 300 mg/（kg·d）] or solvent（propylene glycol） respectively.The levels of the fasting blood glucose（FBG）,triglycerides（TG）,total cholesterol（TC）,free fatty acids（FFA）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,total antioxidation capability（T-AOC）,insulin（INS）,tumor necrosis factor alpha（TNF-α） and leptin in serum of the experimental animals were examined.Insulin sensitivity index（ISI）,liver index,kidney index and the relative weight of abdominal adipose tissue were calculated.ResultsHigh-dose LF [300 mg/（kg·d）] treatment significantly decreased the levels of FBG,TG,TC,LDL-C,FFA,TNF-α,leptin,liver index and kidney index in diabetic rats,and also increased the levels of T-AOC,ISI and the relative weight of abdominal adipose tissue.Preventive treatment significantly suppressed the increase in levels of FBG,TG,TC,LDL-C and liver index,and the decrease in relative weight of abdominal adipose tissue caused by combination of high-fat-high-sugar diet and low dose STZ（35 mg/kg） injection;and it also greatly increased the levels of T-AOC.ConclusionLF has significantly suppressive effect on the increase in levels of blood glucose and on the lipid metabolic disorders in type 2 diabetic rats.

关 键 词：甘草黄酮 2型糖尿病 血糖 血脂 胰岛素抵抗 

分 类 号：R-332[医药卫生]