糖尿病常用中药中常见成分的α-葡萄糖苷酶和α-淀粉酶活性抑制作用（英文）  

α-Glucosidase and α-Amylase Inhibitory Activity of Common Constituents from Traditional Chinese Medicine Used for Diabetes Mellitus

作　　者：叶晓平 宋纯清 袁萍[1,2] 茅仁刚[1,2] 

机构地区：[1]上海新康制药厂,上海201418 [2]上海师范大学,上海200234

出　　处：《中国天然药物》2010年第5期349-352,共4页

摘　　要：目的:从临床常用的治疗糖尿病中药中寻找α-葡萄糖苷酶和α-淀粉酶活性抑制剂,为中药治疗糖尿病提供物质基础。方法:收集存在于常用治疗糖尿病中药中的常见成分,体外检测它们对α-葡萄糖苷酶和α-淀粉酶活性抑制活性抑制作用。结果:有24个成分有显著抑制α-葡萄糖苷酶活性(IC50<100μg·mL?1),20个化合物对α-淀粉酶有显著抑制活性,其中10个成分对两种酶均有很强的抑制作用。结论:常用的治疗糖尿病中药中的常见成分高达40%以上对α-葡萄糖苷酶和/或α-淀粉酶有抑制作用,为含有这些成分的中药治疗糖尿病提供部分酶学依据。AIM： To screen α-glucosidase and α-amylase inhibitors from common natural products found in traditional Chinese medicines （TCM） usually used for diabetes mellitus clinically and try to illustrate scientific evidence Of those TCMs for diabetes mellitus. METHOD： 43 common natural products in TCM for diabetes mellitus were used for assay for α-glucosidase and α-amylase inhibitory activities in vitro. RESULTS： More than 24 and 20 compounds showed obvious α-glucosidase and α-amylase inhibitory activities respectively. Among them, 10 compounds revealed strong inhibition on both α-glucosidase and α-amylase. CONCLUSION： More than 40% test compounds possess inhibitory activities on α-glucosidase and/or on α-amylase, partially interpreting the reasons for these TCMs against diabetes mellitus.

关 键 词：糖尿病 中药 Α-葡萄糖苷酶抑制剂 Α-淀粉酶抑制剂 

分 类 号：R965.1[医药卫生—药理学]