调强放疗联合化-热疗治疗食管癌的疗效  

Efficacy of combined IMRT with chemotherapy and thermotherapy for esophageal cancer

作　　者：朱海文[1] 火旭东[1] 陈龙云[1] 王汉华[1] 王飞[1] 

机构地区：[1]盐城市第三人民医院放疗科,224001

出　　处：《江苏医药》2010年第18期2176-2178,共3页Jiangsu Medical Journal

摘　　要：目的探讨调强放疗(IMRT)联合化-热疗治疗食管癌的近期疗效。方法对78例经病理证实的食管癌患者实施调强放疗,处方剂量PTV为60～66Gy,每次分割量1.8～2.1Gy。化疗方案:5-氟尿嘧啶(5-FU)750mg/d,5d;顺铂(DDP)20mg/d,5d;放疗期热疗每周2次,共6～12次。结果 78例中完全缓解(CR)50例,部分缓解(PR)25例,稳定(NC)3例,近期有效率为96.1%。1年生存率为80.8%。急性毒副反应主要表现骨髓抑制,特别是白细胞减少。结论 IMRT联合化-热疗治疗食管癌近期疗效好,毒副反应可耐受。Objective To investigate the short-term efficacy of intensive modulated radiation therapy（IMRT） combined with chemotherapy plus thermotherapy for esophageal cancer.MethodsSeventy-eight patients with pathologically confirmed esophageal cancer were received IMRT with a prescribed PTV dose of 60-66 Gy,1.8-2.1 Gy/f,5 f/w. Meanwhile,all patients were administrated one course of chemotherapy,which consisted of fluorouracil 750 mg and cisplatin 20 mg per day for 5 days and a total of 6 to 12 times heat therapy twice a week.Results Of 78 cases,complete remission of the primary tumor was seen in 50 cases,partial remission in 25 cases and no change in 3 cases.The short-term effectiveness rate was 96.1%.The one-year survival rate was 80.8%.The acute toxic effects were manifested primarily as bone marrow suppression,especially as neutropenia.ConclusionIMRT combined with chemotherapy plus thermotherapy has a good short-term efficacy with endurable toxic effects in the patients with esophageal cancer.

关 键 词：食管癌 调强放疗 热疗 

分 类 号：R735[医药卫生—肿瘤]