尾加压素Ⅱ在吸烟大鼠脑血管内皮细胞的表达  

Expression of Urotensin-Ⅱ on Vascular Epithelium in Smoked Rat Brain

作　　者：刘菲[1] 柳宗兰[2] 王一沙[1] 

机构地区：[1]沈阳医学院沈洲医院神经内科,辽宁省沈阳市110002 [2]中国医科大学附属第一医院神经内科,辽宁省沈阳市110001

出　　处：《中国动脉硬化杂志》2010年第8期636-638,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的观察不同吸烟量大鼠脑内血管内皮细胞尾加压素Ⅱ的表达,初步探讨吸烟导致脑缺血的发病机制。方法健康Wistar大鼠60只,分为正常对照组、短期大量吸烟组、长期大量吸烟组、长期小量吸烟组、戒烟组及非吸烟组。通过免疫组织化学法观察大鼠脑血管内皮细胞尾加压素Ⅱ的表达。结果正常对照组及非吸烟组尾加压素Ⅱ表达极少,余各组可见有不同程度表达,且与正常对照组比较差异有显著性(P<0.05)。结论吸烟可致脑血管内皮细胞尾加压素Ⅱ表达增加,可能是吸烟致动脉粥样硬化的主要途径之一。Aim To observe expression of urotensin-Ⅱ（U-Ⅱ） on vascular epithelium in smoked rat brain,and to discuss the mechanism of ischemia in brain caused by smoking. Methods 60 health Wistar rats were divided into 6 groups： normal group,short-time and big-dose smoking group,long-time and big-dose smoking group,long-time and small-dose smoking group,giving-up smoking group,control group.We obtained brain following experiment ending and observed expression of U-Ⅱ in smoked rat by immunohistochemistry stain. Results The expression of U-Ⅱ in normal group and control group was weak.The significant different expression was observed in other groups（P〈0.05）.Giving up smoking can reduce the expression of U-Ⅱ. Conclusion Smoking can make more U-Ⅱ expression in endothelial cell.There is prominent dose-dependent and time-dependent relationship between smoking and expression of U-Ⅱ.Giving up smoking can reduce expression of U-Ⅱ.The increase of U-Ⅱ plays an important role in ischemic cerebral vascular disease（ICVD） caused by smoking.

关 键 词：脑梗死 尾加压素Ⅱ 吸烟 内皮细胞 

分 类 号：R363[医药卫生—病理学]