CD147及Ⅳ型胶原蛋白在原发性胃癌中的表达及其临床意义  

Expression and significance of CD147 and collagen IV in gastric carcinoma

作　　者：李友全 邢君 闫峥峥 

机构地区：[1]山西省晋中市第一人民医院普通外科,030600 [2]山西省晋中市第一人民医院肝胆外科,030600

出　　处：《肿瘤研究与临床》2010年第10期684-685,共2页Cancer Research and Clinic

摘　　要：目的 探讨CD147和Ⅳ型胶原蛋白在原发性胃癌中的表达及其临床意义.方法应用免疫组织化学（SP）法检测119例胃癌患者癌组织标本及正常胃组织中CD147和Ⅳ型胶原蛋白的表达情况,并结合临床相关因素进行分析.结果在胃癌组织中,CD147蛋白阳性表达率为83.2%（99/119）,Ⅳ型胶原蛋白阳性表达率为31.9%（38/119）,CD147和Ⅳ型胶原蛋白在胃癌组织中的表达与胃癌患者是否发生淋巴结转移、浸润深度、临床分期差异均有统计学意义（P＜0.05）.胃癌组织中CD147和Ⅳ型胶原蛋白的表达呈负相关（P＜0.01）.结论胃癌组织中CD147和Ⅳ型胶原蛋白的表达可以作为胃癌基础和临床研究的客观参考指标.Objective To study the expression of CD147 and collagen Ⅳ protein in gastric carcinoma.Methods Immunohistochemical assay was used to detect the expression of CD147 and collagen Ⅳ protein in 119 cases of gastric carcinoma, 20 cases of normal gastric tissues, and the clinical data was analyzed.Results In 119 cases of gastric carcinoma, the positive expression of CD147 protein was 83.2 %（99/119）, the positive expression of collagen Ⅳ protein was 31.9 %（38/119）. The expression of CD147 and collagen Ⅳprotein had relationship with metastasis of lymph nodes,depth of invasion and clinical phases （P 〈0.05）. There was negative significant correlation between the expression of CD147 and collagen Ⅳ protein in gastric carcinoma （P〈0.01）. Conclusion The expressions of CD147 and collagen Ⅳ protein may be used as one of the marks to study gastric carcinoma.

关 键 词：胃肿瘤 CD147蛋白 Ⅳ型胶原蛋白 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]