Galectin-3在膀胱癌中的表达及临床意义  

Clinical Significance of Galectin-3 Expression in Bladder Cancer

作　　者：陈启光[1] 杨琦[1] 张哲[1] 于秀月[1] 单广夷[1] 孔垂泽[1] 

机构地区：[1]中国医科大学附属第一医院泌尿外科,沈阳110001

出　　处：《中国医科大学学报》2010年第9期755-757,共3页Journal of China Medical University

基　　金：辽宁省教育厅高校科研基金资助项目(2004C048)

摘　　要：目的检测Galectin-3在膀胱癌组织中的表达情况,探讨其与膀胱癌临床病理特征之间的关系。方法采用免疫组织化学链霉菌抗生物素蛋白-过氧化物酶法(S-P法)检测45例膀胱癌和6例正常膀胱黏膜组织中Galectin-3的表达,结合临床数据及病理结果,分析其与膀胱癌临床病理特征之间的关系。结果 Galectin-3在膀胱癌中的阳性表达率为62.2%,正常膀胱黏膜中未见表达,差异具有显著统计学意义(P<0.05)。在初发和复发膀胱癌中,其阳性表达率分别为60%和70%,未见统计学差异(P>0.05)。Galectin-3的表达随膀胱癌的病理分级和临床分期的增加而增加,其表达与两者均具有相关性(P<0.05)。结论 Galectin-3在膀胱癌中表达增加,其高表达可作为膀胱癌诊断及判定病理分级和临床分期的重要指标。Objective To examine the galectin-3 expression in bladder cancer and explore the relationship between the galectin-3 expres-sion and the clinicalpathological characteristics of bladder cancer.Methods Immunohistochemical streptavidin-peroxidase（S-P）method was employed to examine the expression of galectin-3 in 45 bladder cancer tissues and 6 normal bladder tissues.The relationship between galectin-3 expression and the clinicopathological parameters was analyzed in bladder cancers.Results The positive rate of galectin-3 ex-pression in bladder cancer was 62.2%,significantly higher than that in 6 normal bladder tissues（P 〈 0.05）.The positive rates of galectin-3 expression in primary cases and recurrent cases were 60% and 70% respectively without significant difference（P 〉 0.05）.The up-regulated expression of galectin-3 was positively correlated with the pathological degree and clinical stage of bladder cancer（P 〈 0.05）.Conclusion Galectin-3 expression is up-regulated in bladder cancer and its increased expression is useful for diagnosis of bladder cancer.Additionally,it could be used as an important index to evaluate the pathological degree and clinical stage of bladder cancer.

关 键 词：GALECTIN-3 膀胱癌 病理分级 临床分期 免疫组化 

分 类 号：R737.14[医药卫生—肿瘤]