NINJ2基因多态性与房山地区汉族脑卒中易感强相关  

Strong association between the NINJ2 gene polymorphism and the susceptibility of stroke in Chinese Han population in Fangshan district

作　　者：陈廓[1] 肖占森[2] 侯淑琴[2] 赵润田[2] 刘岳峰[2] 窦会东[2] 李广平[1] 陶晓明[1] 李峰[1] 周文郁[1] 邱长春[1] 

机构地区：[1]中国医学科学院基础医学研究所,医学分子生物学国家重点实验室,北京100005 [2]北京房山区第一医院检验科

出　　处：《北京大学学报（医学版）》2010年第5期498-502,共5页Journal of Peking University:Health Sciences

基　　金：北京市自然科学基金(7001004);美国中华医学基金(96-657);“十一五”国家科技支撑计划(2006BAI190B)~~

摘　　要：目的:探讨NINJ2基因旁侧的rs11833579位点多态性与房山汉族人群脑卒中的关系。方法:采取横断面病例-对照相关分析。分别采用多聚酶链式反应-限制性片段长度多态性(PCR-RFLP)分析及直接测序技术检测NINJ2的基因型。脑卒中患者790人(其中脑梗塞679人),为北京房山第一医院2003～2008年住院患者;正常对照者811例,为房山区农村查体无脑卒中家族史的无血缘关系汉族正常人群。结果:NINJ2基因rs11833579位点的GG基因型和G等位基因频率在脑梗塞组较对照组明显升高,P均<0.001;脑出血组与对照组比较,G等位基因频率差异有统计学意义(P=0.005)。基因型对血糖、总胆固醇和甘油三酯的影响不大(P>0.05)。结论:NINJ2基因rs11833579位点多态性与房山汉族人群中脑卒中易感强相关。Objective：To investigate the association between the NINJ2 gene rs11833579 polymorphism and stroke in Han Chinese population.Methods：This study was a population-based cross-sectional case-control study.Polymerase chain reaction-restriction fragment length polymorphism（RFLP） and sequencing were used for the detection of NINJ2 genotypes in 790 patients with stroke （679 ischemic stroke） which were Han Chinese population from Fangshan First Hospital and 811 controls which were healthy Han Chinese population without family history of stroke in Fangshan district rural area.Results：In rs11833579 locus of the NINJ2 gene,the frequencies of GG genotype and allele G were higher in ischemic stroke patients than that in controls （P〈0.001）.The frequency of allele G of the NINJ2 gene was higher in cerebral hemorrhage patients than that in controls （P=0.005）.Genotype had little effect on the glucose,total cholesterol and triglyceride.Conclusion：There is significant association between rs11833579 site polymorphism of the NINJ2 gene and risk for stroke in Han Chinese population from Fangshan district.

关 键 词：脑出血 脑梗塞 多态现象 遗传 NINJ2基因 汉族 

分 类 号：R743.3[医药卫生—神经病学与精神病学]