肉瘤间质内注射^(188)Re一硫化铼混悬液的动物实验研究  

Study on interstitial injection of ^(188)Re-sulfide suspension in sarcoma bearing mice

作　　者：闵小锋[1] 张炯[1] 于俊峰[1] 尹端沚[1] 郭子丽[1] 汪勇先[1] 

机构地区：[1]中国科学院上海原子核研究所,上海201800

出　　处：《核技术》1999年第5期293-296,共4页Nuclear Techniques

摘　　要：将１８８Ｒｅ一硫化铼混悬液注射到荷瘤小鼠肉瘤中，结果约８０％－９０％的放射性积聚在肿瘤内；向瘤中心先后两次注射２１．２ＭＢｑ１８８Ｒｅ一硫化铼液后，能有效抑制肉瘤生长，并无明显毒副作用；注射１８８ｂｅ一硫化铼组小鼠外周血ＷＢＣ数尽管比其余组小鼠低，但仍在正常范围内，对骨髓无明显影响。The 188Re-sulfide suspension was injected into sarcoma mice interstitially. The result showed that the ratio of uptake of sarcomas was about 80%-90%, and the growth of sarcoma was depressed in all mice. When 21.2MBq 188Re-sulfide suspension were injected twice in each mouse, no any toxic effect was found. The white blood cells(WBC) in mice injected with 188Re-sulfide suspension was less than those of the other groups, but still within the normal level. No significant effect to the bone marrow was observed.

关 键 词：硫化铼 混悬液 肉瘤 镭188 动物实验 辐射治疗 

分 类 号：R730.55[医药卫生—肿瘤] R738.7[医药卫生—临床医学]