炎症反应中的蛋白质翻译后修饰  

Post-translational Modifications of Proteins in Inflammation

作　　者：谢军[1,2] 彭小蓉[1,2] 张力[1,2] 

机构地区：[1]重庆医科大学儿科学院,重庆市400016 [2]重庆医科大学病理生理学教研室,重庆市400016

出　　处：《医学分子生物学杂志》2010年第5期459-462,共4页Journal of Medical Molecular Biology

基　　金：资助项目：国家自然科学基金（No.30900651）,重庆市教委科学技术研究项目（No.KJ090304）

摘　　要：炎症相关的信号转导蛋白、转录因子、炎性介质、组蛋白等可在炎症发生发展过程中发生磷酸化、乙酰化、泛素化、苏素化、甲基化等一系列翻译后修饰。这些化学修饰可高效调节相关蛋白质的功能活性及基因表达水平，不同化学修饰之间还可相互作用，共同影响炎症的发生、发展与转归；而异常的翻译后修饰与炎症相关性疾病关系密切。Post-translational modifications such as phosphorylation, acetylation, ubiquitina- tion, sumoylation and methylation play a significant role in the inflammatory progress. They often occur on inflammation-related signal transduetion proteins, transcription factors, inflammatory mediators, histones and so on. These chemical modifications regulate the functions of related proteins and the expression of related genes. Interactions of different chemical modifications collectively modulate the development and prognosis of inflammation. In contrast, abnormal post-translational modification is closely associated with inflammation-related diseases.

关 键 词：炎症反应 翻译后修饰 乙酰化 泛素化 苏素化 

分 类 号：R364.5[医药卫生—病理学] Q518.4[医药卫生—基础医学]