An efficient and green preparation of 5-aminophosphonate substituted pyrimidine nucleosides under solvent-free conditions  

作　　者：Xin Ying Zhang Ying Ying Qu Xue Sen Fan 

机构地区：[1]School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, China

出　　处：《Chinese Chemical Letters》2010年第10期1191-1194,共4页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China(Nos.20772025 and 20972042);the Program for Science & Technology Innovation Talents in Universities of Henan Province(No.2008HASTIT006);Innovation Scientists and Technicians Troop Construction Projects of Henan Province(No.104100510019);the Natural Science Foundation of Henan Province(Nos.092300410192 and 094300510054)

摘　　要：An environmentally benign and highly efficient one-pot preparation of α-aminophosphonates under solvent-free conditions was developed. By employing this method, 5-aminophosphonate substituted pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-forrnyl-2＇-deoxyuridine, aniline and dimethylphosphite.An environmentally benign and highly efficient one-pot preparation of α-aminophosphonates under solvent-free conditions was developed. By employing this method, 5-aminophosphonate substituted pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-forrnyl-2＇-deoxyuridine, aniline and dimethylphosphite.

关 键 词：AMINOPHOSPHONATE 5-Substituted pyrimidine nucleoside Solvent-free reaction Green synthesis 

分 类 号：O627.51[理学—有机化学] TQ244.2[理学—化学]