胃癌组织中GHR的表达与组织分化相关性的研究  

Expression of growth hormone receptor in human gastric cancer tissue and its correlation with the differentiation

作　　者：袁媛[1] 李苏宜[2,3] 

机构地区：[1]徐州市中心医院肿瘤内科,江苏徐州221009 [2]东南大学医学院 [3]东南大学附属中大医院临床肿瘤中心,江苏南京210009

出　　处：《中国肿瘤外科杂志》2010年第4期207-209,212,共4页Chinese Journal of Surgical Oncology

摘　　要：目的研究人胃癌组织生长激素受体(GHR)的表达情况及其与肿瘤临床病理特点的关系。方法采用免疫组织化学法检测32例胃癌组织及7例正常胃黏膜组织的GHR的表达,并回顾性分析胃癌患者临床资料,分析GHR的表达与肿瘤分化程度的关系。结果胃癌组织中GHR表达阳性率为65.6%(21/32),正常组织GHR表达阳性率为85.7%(6/7),二者存在统计学差异(P<0.05)。GHR表达与组织分化程度相关(P<0.05)。GHR表达与临床分期、性别和年龄均无关(P>0.05)。结论胃癌组织与正常黏膜GHR表达存在差异,胃癌组织中不同分化程度的GHR的表达也存在差异。Objective To investigate the expression of growth hormone receptor in human gastric cancer tissues. Methods The GHR was detected in samples of the human gastric cancer （ 32 cases） and normal tissues （7 cases） by immunohistochemistry technique. Results The GHR expression positive rate was 65.6% （21/32） in the human gastric cancer tissue and 85.7% （6/7） in the distal normal tissues. There were statistic difference between them （P 〈 0.05）. There were statistic differences among the gastric cancer tissues of different differentiation, different tissue type（P 〈 0.05 ）. There were no statistic differences among the gastric cancer tissues of different clinical stage, different gender and different age ranges （P 〉 0.05）. Conclusions GHR expression in both between gastric cancer and normal tissues, also in gastric cancer are different.

关 键 词：生长激素受体 胃癌组织 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]