结构脂肪乳对胃肠道肿瘤患者术后细胞免疫功能的影响  

The effect of structolipid on immunologic function of patients with gastrointesti-nal tumor after operation

作　　者：张彦波[1] 刘鑫[1] 邵峰[1] 辛福泽[1] 米曰堂[1] 郭震[1] 杨道贵[1] 

机构地区：[1]聊城市人民医院胃肠外科,山东聊城252000

出　　处：《中国肿瘤外科杂志》2010年第4期225-227,238,共4页Chinese Journal of Surgical Oncology

摘　　要：目的观察结构脂肪乳(STG)、中/长链脂肪乳(MCT/LCT)和长链脂肪乳(LCT)对胃肠道肿瘤患者术后细胞免疫功能的影响。方法选择2008年8月至11月间收治的64例经病理证实为胃肠道肿瘤的患者,采用信封法随机分为3组:STG组22例、MCT/LCT组22例和LCT组20例。术后1~5d接受等氮、等热量的PN支持。观察患者术前、术后第1天及第6天外周血T淋巴细胞亚群CD3^+、CD4^+、CD8^+比率及CD4^+/CD8^+比值的变化。结果术后第1天,3组患者CD3^+、CD4^+比率及CD4^+/CD8^+比值均有所下降;术后第6天,STG组和MCT/LCT组CD3^+、CD4^+比率及CD4^+/CD8^+比值上升,而LCT组上升不明显,且STG组与LCT组差异有统计学意义。结论术后早期应用结构脂肪乳支持能够改善患者的细胞免疫功能,促进患者术后康复。Objective To investigate the effect of structolipid on immunologic function of patients with gastrointestinal tumor after operation. Methods 64 cases with gastrointestinal tumor were divided into 3 groups, namely STG group, MCT/LCT group and LCT group. The total parenteral nutrition contained struetolipid, medium-chain and long-chain triglycerides or long-chain triglyceride was transfused from 1st day to 5th day after operation. CD3＋ , CD4 ＋ , CD8 ＋ , CD4＋/CD8＋ of the 3 groups were detected on the day before the operation, 1 st and 6th day after operation. Results CD3 ＋ , CD4 ＋ , CD8 ＋ , CD4＋/CD8 ＋ of the 3 groups were dropped after operation and increased after 5 days of parenteral nutrition. However, the increase was obviously in STG group and MCT/LCT group, while the LCT group increase a little. Conclusions Early total parenteral nutrition contained structolipid may have beneficial effect on improving immunologic function and the recovery of patients with gastrointestinal tumor after operation.

关 键 词：结构脂肪乳 中/长链脂肪乳 长链脂肪乳 胃肠道肿瘤 细胞免疫功能 术后 营养支持 肠外营养 

分 类 号：R735[医药卫生—肿瘤]