联合检测TPSA、FPSA、FPSA/TPSA对前列腺癌的诊断价值  

Diagnostic value of combined determination of TPSA,FPSA,FPSA/TPSA in Prostate Cancer

作　　者：张丽萍[1] 曹玉萍[1] 刘学公[1] 

机构地区：[1]安徽省立医院核医学科,安徽合肥230001

出　　处：《中国肿瘤外科杂志》2010年第5期295-297,共3页Chinese Journal of Surgical Oncology

摘　　要：目的 探讨血清中总前列腺特异性抗原（TPSA）、游离前列腺特导性抗原（FPSA）及FPSA/TPSA比值在前列腺疾病诊断中的价值.方法 采用全自动电化学发光分析技术,检测45例健康男性,40例前列腺增生（BPH）患者和32例前列腺癌（PCa）患者血清中的TPSA和FPSA含量,计算FPSA/TPSA比值,并进行统计学分析.结果 BPH组及PCa组的TPSA和FPSA值均显著高于正常对照组,而PCa组FPSA/TPSA比值显著低于正常对照组和BPH组.当TPSA值在4.1～60.0 ng/mL时,BPH和PCa出现交叉重叠现象,单靠TPSA一项指标难以提高PCa诊断率.BPH组的FPSA/TPSA很少〈0.11,PCa组的FPSA /TPSA很少〉0.20.由此,FPSA /TPSA比值的测定可用于BPH和PCa的鉴别诊断.结论 联合检测血清中TPSA、FPSA的含量及FPSA/TPSA比值,可大大提高PCa的诊断率,对PCa早期诊断及鉴别诊断有重要意义.Objective To evaluate the value of serum TPSA,FPSA and FPSA/TPSA ratio in the diagnosis of prostate disease. Methods To adopt the automatic electrochemical process to determine the level of TPSA and FPSA among 40 prostatic hyperplasia（BPH） patients and 32 prostate cancer（PCa） patients, then figure out the FPSA/TPSA ratio, and castled out statistical analysis. Results The FPSA/TPSA ratio of BPH group and PCa group were higher than normal control group, the FPSA/TPSA ratio of PCa group were significantly lower than those in normal control group and BPH group. There was overlapping phenomenon when TPSA were 4.1- 60.0 ng/mL, it is not enough to depend only on TPSA. BPH group were hardly observed when FPSA/TPSA 〈 0.11, PCa group were hardly observed when FPSA/TPSA 〉 0.20, so the value of FPSA/TPSA can be used to distinguish BPH and PCa. Conclusions The combined determination of TPSA, FPSA, FPSA /TPSA can greatly improve the diagnostic rate of PCa, and has important significance in early diagnosis and differential diagnosis for PCa.

关 键 词：前列腺特异性抗原(PSA) 总前列腺特异性抗原(TPSA) 游离前列腺特异性抗原(FPSA) 前列腺癌 前列腺增生 

分 类 号：R737.25[医药卫生—肿瘤]