含黄酮的三价铁配合物合成及其药理性质(英文)  

Trivalent Iron Chelator with Flavone Moiety:Synthesis and Pharmacological Properties

作　　者：Emel Yildiz Sadet Karabulut Neslihan S.Pinar Yusuf Karatas Figen Doran 

机构地区：[1]Cukurova大学文理学院化学系 [2]Cukurova大学医学院药理学系 [3]Cukurova大学医学院病理学系

出　　处：《无机化学学报》2010年第10期1743-1749,共7页Chinese Journal of Inorganic Chemistry

基　　金：TUBITAK,Ankara基金(No.TBAG107T908,2008)资助

摘　　要：3,3,4,7-四羟基黄酮与1,3-二环己基碳二亚胺在4-二甲胺吡啶存在下反应,得到2,2-双(3,3,4,7-四羟基黄酮)1,3-二环己基碳二亚胺。三价金属离子与上述合成得到的配体螯合,对此四面体结构的双核Fe(Ⅲ)配合物的血液学及病理学数据进行了讨论,同时研究了合成的配体作为螯合剂清除鼠肝胰组织中超载的铁的能力。结果表明作为口服药其作为双齿配体的螯合能力与市售用于治疗地中海贫血的药物"去铁敏"相近。2,2-bis（3,3,4,7-tetra hydroxyflavone） 1,3-dicyclohexyl carbamine,3,3,4,7-tetra hydroxyflavone was obtained by the reaction of 3,3,4,7-tetra hydroxyflavone with 1,3-dicyclohexyl carbodiimid in presence of 4-dimethyl amino pyridine.The above obtained ligand can chelate with trivalent metal ion.Hematologic and pathologic data of the dinuclear iron complex with tetrahedral geometry were discussed.The ability of the synthesized ligand as a chelator to remove overloaded iron from rat liver and spleen tissues was studied.The results show that the chelate effect of the ligand as the bidentate is near that of desferrioxamine available in market in oral applications for the treatment of β-thalassemia.

关 键 词：螯合 黄酮 铁(Ⅲ)离子 药物治疗 地中海贫血 

分 类 号：O614.811[理学—无机化学]