紫杉醇联合FOLFOX4方案治疗晚期胃癌33例临床观察  

Clinical observation of paclitaxel combined with FOLFOX4 for advanced gastric cancer

作　　者：李永峰[1] 

机构地区：[1]河南省林州市肿瘤医院,河南林州456550

出　　处：《医学信息（医药版）》2010年第11期28-30,共3页

摘　　要：目的：评价紫杉醇联合FOLFOX4（奥沙利铂、亚叶酸钙、5－氟尿嘧啶）方案治疗晚期胃癌的临床疗效和不良反应。方法：33例胃癌晚期患者给予紫杉醇135mg／m^2dl，OXA85mg／m^2d2，CF200mg／m^2d2、3，5-FU400mg／m^2d2、3，5-FU600mg／m^2（持续22小时）d2、3。16天为1个周期，疗程4周期。结果：33例患者中完全缓解3例，部分缓解16例，稳定10例，进展4例，总有效率57．58％；中位疾病的进展时间为5．12个月。常见的毒性反应为白细胞和中性粒细胞减低，消化道反应和周围神经毒性等。结论：紫杉醇联合FOLFOX4方案治疗晚期胃癌疗效显著．毒性反应患者能耐营．可延长患者生存期．Objective To investigate the efficacy and toxicity of paclitaxel combined with FOLFOX4 （oxaliplatin, calcium folinate, 5-fluorouracil） for advanced gastric cancer. Methods 33patients with advanced gastric cancer were injected with paclitaxel 135mg/m^2dl, OXA85mg/m^2d2, CF200 mg/m^2d2, 3, 5-FU400 mg/m^2d2, 3, 5-FU600 mg/m^2 （for 22 hours） d2, 3, for 4 cycles, with every 16days in a circle. Results Of 33patients, 3 cases had complete remission, 16cases had partial remission, 10cases had stable disease and 4 cases had progressive disease, with the total response rate of 57.58%, and the median time to progression was 5.12 months. The most common adverse reaction included leueopenia, neutronpenia, gastrointestinal tract reaction and peripheral neuropathy, etc. Conclusion paclitaxel combined with FOLFOX4 in the treatment of advanced gastric cancer has remarkable response and tolerable toxicity, which may contribute to the prolonged survival of the patients.

关 键 词：紫杉醇 FOLFOX4 晚期胃癌 

分 类 号：R735[医药卫生—肿瘤]