立体定向双侧多靶点联合损毁治疗难治性精神病210例  

Bilateral stereotactic multi-target radiofrequency ablation for 210 patients with intractable psychosis

作　　者：黎柏源[1] 白万胜[1] 孙平安[1] 应敬国[1] 胡彪[1] 周波[1] 赵东明[1] 高云[1] 刘娜[1] 文雅[1] 薛宏丽[1] 

机构地区：[1]解放军第323医院神经外科,陕西西安710054

出　　处：《中华神经外科疾病研究杂志》2010年第5期414-417,共4页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的探讨立体定向双侧多靶点联合损毁对难治性精神病的临床疗效。方法立体定向下经CT、电阻抗和微电极电生理核团定位,对210例难治性精神病患者,采用杏仁核、内侧隔区、扣带回等多靶点组合射频热凝治疗。术后6个月,应用临床疗效总评量表(CGI)、简明精神病评定量表(BPRS)和阳性和阴性综合量表(PANSS)进行疗效评定。结果依据减分率标准,210例患者中,显著进步160例,进步42例,无变化8例。手术前后量表评分有显著差异(P<0.05)。结论多靶点组合的立体定向技术设计和亚核团的准确定位,对提高难治性精神病疗效,降低并发症有较大意义。Objective To analyze the significance of stereotactic multi-target radiofrequency ablation on intractable psychosis.Methods A total of 210 patients with intractable psychosis were included in the study. The targets of the amygdale,medial septum and cingulate gyrus were treated by radiofrequency ablation after stereotactically located by CT,electric impedance and microelectrode. The therapeutic effects were evaluated 6 months postoperation by clinical global impressions scale （CGI）,brief psychiatric rating scale （BPRS） and the positive and negative syndrome scale （PANSS）. Results Based on the reduction rate,obvious improvement achieved in 160 patients,improvement in 42 patients and no improvement in 8. There was significant difference in score between preoperation and postoperation （P0.05）.Conclusion It might be of great significance to improve the effect and decrease the complication in treating intractable psychosis by accurate multi-target location of subnuclei with stereotactic technique.

关 键 词：立体定向 难治性精神病 射频毁损 

分 类 号：R749.05[医药卫生—神经病学与精神病学]