ABO血型B_2和AB_2亚型血清学特征及人群分布研究  

Serologic Characteristics and Population Distribtion of Subtypes B_2 and AB_2 of ABO Blood Group

作　　者：段福才[1] 王明禄[2] 周克礼 李大元[1] 张秦永 马爱萍[2] 杨荷英[1] 李建华[1] 刘园园[2] 肖芳[1] 高映雪[1] 

机构地区：[1]白银市红十字中心血站,甘肃白银730900 [2]甘肃省红十字血液中心,甘肃兰州730046

出　　处：《中国实验血液学杂志》2010年第5期1331-1334,共4页Journal of Experimental Hematology

摘　　要：本研究旨在探讨ABO血型B2和AB2亚型的血清学特征、遗传背景和人群分布。采用经典的血型血清学试验技术检测先证者及其家庭成员血型,用自己研制的抗B1试剂血清对献血者进行B1/B2和AB1/AB2亚型分布调查。结果发现:先证者为AB2亚型、其子为B2亚型,先证者血清中含有抗B1抗体;2 318名B型献血者中发现3名为B2亚型,826名AB型献血者中发现2名为AB2亚型;先证者及3名献血者家系调查B2抗原均具有血型遗传学特征。结论:B2/AB2亚型是家族遗传,B2和AB2亚型分别占B型和AB型的0.129%、0.224%。This study was aimed to investigate the serologic characteristics,genetic background and population distribution of B2 and AB2 subtype in Chinese ABO blood group.The classic blood group serological technology was used to detect ABO blood group of the propositus and their family members,the anti-B1 serum prepared by ourself was used to investigate the distribution of B1/B2 and AB1/AB2 subtype of the blood donor.The results indicated that the antigen of propositus was AB2 subtype and that of his child was B2 subtype.The anti-B1 antibody was detected in blood serum of propositus;the antigen of 3 from 2318 blood donors with B blood group were found to be B2 subtype,the antigen of 2 from 826 blood donors with AB blood group were found to be AB2 subtype.The investigation on propositus and the 3 B2 blood donor families showed that B2 antigen displays genetic characteristics of blood group.It is concluded that B2/AB2 subtype is from family inheritance,while B2 subtype is amounted to 0.129% in B blood group,and AB2 subtype is amounted to 0.224% in AB blood group.

关 键 词：ABO血型 B2/AB2亚型 抗B1 人群分布 家系调查 

分 类 号：R457.11[医药卫生—治疗学]