缝隙连接蛋白在动脉粥样硬化形成和防治中的作用  

The role of gap junction connexin in the formation,precaution and treatment of atherosclerosis

作　　者：陈敏[1] 蒋丽萍[1] 洪涛[2] 

机构地区：[1]南昌大学药学系,江西南昌330006 [2]南昌大学第一附属医院神经外科,江西南昌330006

出　　处：《中国药理学通报》2010年第10期1271-1274,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 30760286)

摘　　要：缝隙连接(gap junctions,GJ)是由相邻细胞间许多缝隙连接蛋白(connexin,Cx)六聚体组成,为细胞间无机离子、水溶性小分子(<1 ku)、代谢产物提供电和化学交流,从而协调细胞生长和分化的生理过程。动脉粥样硬化形成机制非常复杂,越来越多的研究表明Cx重构参与了动脉粥样硬化形成各过程,该文主要对Cx在动脉粥样硬化形成和防治中的作用作一综述。Gap junctions,formed by homomeric or heteromeric hexamers that are assembled by same or different kinds of connexins,allow the exchange of inorganic ion,small molecules（1 ku） and metabolites between adjacent cells,thus providing a mechanism for synchronizing the responses of groups of cells to environmental electrical and chemical stimuli,and coordinating physiological processes of cell growth and differentiation.The mechanism of atherosclerosis formation is relatively complex. There has been increasing amount of evidence indicating that the remodelling of gap junction connexin is involved in the formation of atherosclerotic process.Here,we review the role of gap junction connexin in the formation,precaution and treatment of atherosclerosis.

关 键 词：缝隙连接蛋白 动脉粥样硬化 内皮细胞 白细胞 平滑肌细胞 斑块 

分 类 号：R-05[医药卫生] R341