3.0T 1H-MRS在胰头癌中的应用研究  

The application of in vivo proton MR spectroscopy in pancreatic carcinoma at 3.0T

作　　者：姚秀忠[1] 曾蒙苏[1] 孙非 王鹤 饶圣祥[1] 周纯武[3] 

机构地区：[1]复旦大学附属中山医院放射科,上海200032 [2]GE中国Health care [3]中国医学科学院肿瘤医院放射科,北京100210

出　　处：《放射学实践》2010年第10期1153-1156,共4页Radiologic Practice

基　　金："十一五"国家科技及支撑课题(2007BAI05B05)

摘　　要：目的:应用3.0T磁共振1H-MRS探查胰头癌及正常胰腺的代谢特征。方法:在3.0T磁共振上,平均年龄匹配的28个正常志愿者的胰头与25个由手术病理证实的胰头癌进行呼吸门控1H-MRS检查,单体素定位通过横轴面、冠状面及矢状面呼吸门控T2WI成像完成。所有波谱资料应用SAGE软件后处理。位于4.7ppm的非水抑制的内参水作为参照物进行其它代谢物的相对定量分析。应用统计学方法分析比较正常胰腺与胰腺癌的不同代谢物峰下面积之比。结果:在正常胰头及胰头癌的1H-MRS谱线上,主要观察到4个波峰:位于5.4～5.6ppm的脂肪酸峰、位于4.7ppm的残余水峰、位于3.2ppm的胆碱代谢产物峰,以及位于1.3ppm的(次)甲基脂类代谢物。正常胰腺的脂水峰下面积比(6.754×10-3±0.007)与胆碱内参水峰下面积比(1.897×10-3±0.002)统计学上高于胰腺癌[(3.162×10-3±0.004),P=0.039;(0.544×10-3±0.001),Pp=0.000013)];正常胰腺的脂肪酸与脂类代谢物峰下面积比(40.349×10-3±0.057)统计学上小于胰腺癌[(102.904×10-3±0.140),P=0.028)];正常胰腺与胰腺癌的脂肪酸与内参水峰下面积比及胆碱与脂肪峰下面积比无统计学差异。结论:在3.0T磁共振上,相对于正常胰腺组织,胰腺癌的脂水比及胆碱内参水比较小,而脂肪酸与脂肪之比较高。Objectives：To prospectively identify metabolic features of pancreatic carcinoma and normal pancreas by in vivo proton （hydrogen 1） magnetic resonance （MR） spectroscopy at 3.0T.Methods：Averagely age-matched 28 healthy volunteers and 25 patients with pancreatic carcinoma in the head of pancreas confirmed by histopathology underwent axial, coronal and saggital respiration-triggered T2WI for location of the single voxel.Respiration-triggered 1H-MR spectroscopy was used for detection of metabolites within the head of normal pancreas and cancerous tissue.All spectrum data were processed in a SAGE software.The un-suppressed internal water at 4.7ppm was used as an internal reference for determination of metabolite concentrations.Each ratio among the different peak areas was statistically evaluated between normal pancreas and pancreatic carcinoma.Results：The following four main groups of spectrum were detected： the peak of fatty acids at 5.4ppm,residual water at 4.7ppm,choline metabolites at 3.2ppm and lipids at 1.3ppm.Ratios of lipid/water without water suppression （6.754×10-3±0.007） and choline/internal water （1.897×10-3±0.002） in normal pancreas were greater than those in pancreatic cancer （3.162×10-3±0.004,P=0.039;0.544×10-3±0.001,P=0.000013） respectively.The ratio of fatty acids/lipid in normal pancreas （40.349×10-3±0.057） was smaller than that in pancreatic cancer （102.904×10-3±0.140,P=0.028）.Ratios of fatty acids/internal water and choline/lipid didn＇t reach statistical difference.Conclusion：Compared to normal pancreas,the decreased ratios of lipid/water without water suppression and choline/internal water and higher ratio of fatty acids/lipid might be suggested as metabolic features of pancreatic carcinoma at 3.0T.

关 键 词：胰腺肿瘤 核磁共振 波谱学 诊断 

分 类 号：R735.9[医药卫生—肿瘤]