HPV感染与宫颈病变相关性的初步研究  

A Study of the Correlation between HPV and Cervical Leision

作　　者：张玉新[1,2] 李维强[1] 陈拉妮[1] 

机构地区：[1]广东省顺德第一人民医院,528300 [2]广东省广州市花都区妇幼保健院,510250

出　　处：《中国医药指南》2010年第30期177-179,共3页Guide of China Medicine

基　　金：广东省医学科研基金项目(A647);佛山市医学类科技攻关项目(200708134)

摘　　要：目的探讨高危型人乳头瘤病毒(HPV-16、18)在各级宫颈病变中的检测及意义。方法将2006年1月至2009年7月在顺德第一人民医院住院或妇科门诊就诊的宫颈疾病患者及健康体检者共1833例作为研究对象。进行宫颈HPV-DNA及TCT(薄层液基细胞学检测Liquid-based Thinprep Cytologic test)检测,对阳性者行阴道镜下检查并对可疑部位组织行病理活检。结果 HPV总阳性率为9.6%,TCT检测中ASCUS、LSIL、HSILHPV阳性率分别为22.2%、62.7%、68.4%,ASCUS组与其余两组比较有显著性差异。HPV阳性与病理检查结果的总阳性符合率65.9%,TCT阳性者和病理检查结果的总阳性符合率为80.5%,但随着病理级别的升高,HPV和TCT阳性率也在升高。结论高危型HPV感染是宫颈癌前病变和宫颈癌的主要致病因素,宫颈细胞学检测和HPV联合检测对宫颈癌的筛查、确诊都有重要意义。Objective To investigate the significance of the human papilloma virus（HPV-16,18） types detected in cervical leision screening. Methods The cervical specimens from 1833 female patients or health examination who received cervical cancer screening in our hospital during January 2006 to July 2009 were selected for HPV detecting by DNA and Liquid-based Thinprep Cytologic test, the positive specimens of the patients received colposcopy with multiple biopsy. Results The HPV positive rate was 9.6%. The positive rate of ASCUS, LSIL, HSIL was 22.2%, 62.7%, 68.4%, respectively. The difference between the ASCUS group and other two groups had statistical significance. The consistency between the results of the HPV and pathological diagnosis of biopsy was 65.9%. The consistency between the results of TCT and pathological diagnosis of biopsy was 80.5%. HPV infection rates and the TCT positive rate increased with the level of cervical lesions increased. Conclusions The infection of high risk HPV is the main major etiological factor of cervical intreapithelial neoplasia and cervical carcinaoma. TCT joint detection with HPV can prevent misdiagnosis and improve diagnostic accuracy.

关 键 词：人乳头状瘤病毒 薄层液基细胞学检测 宫颈上皮内瘤样变 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]