乳腺癌术后辅助治疗中同步与序贯放化疗疗效的荟萃分析  

Concurrent versus sequential adjuvant radio-chemotherapy after mastectomy for breast cancer： a Meta-analysis

作　　者：马睛[1] 刘雅丽[3] 郑忠青[2] 任尧尧[1] 杨克虎[3] 马力[1] 

机构地区：[1]天津医科大学总医院肿瘤科,300052 [2]天津医科大学总医院内科,300052 [3]兰州大学基础医学院循证中心

出　　处：《中华全科医师杂志》2010年第10期723-725,共3页Chinese Journal of General Practitioners

摘　　要：利用计算机与手工检索，收集2009年2月以前乳腺癌术后同步与序贯放化疗疗效对比的4个随机对照试验（1539例），使用RevMan5．0软件进行统计学分析。结果表明，术后同步放化疗与序贯放化疗相比较可降低腋窝淋巴结阳性患者的局部复发率（3．8％与8．4％，P=0．003）。两种干预措施五年总生存率、五年无病生存率、无转移生存率比较，差异无统计学意义（均P〉0．05）。提示术后同步放化疗在降低腋窝淋巴结阳性患者的局部复发率上明显优于序贯放化疗。With computer and manual search of literatures on the comparison of concurrent with sequential adjuvant radio-chemotherapy after mastectomy for breast cancer, 4 eligible randomized controlled trials were found; the RevMan 5.0 software was used for Meta-analysis. The results showed that concurrent radio-chemotherapy reduced local recurrence more prominently than sequential radio-chemotherapy in patients with positive axillary lymph nodes （P = 0. 003 ）. However, differences in 5-year overall survival, 5-year disease-free survival and metastasis-free survival between two groups were not significant （P = 0. 670, P =0. 200, P =0. 350）.

关 键 词：乳腺肿瘤 META分析 

分 类 号：R737.33[医药卫生—肿瘤]