丝裂霉素、长春花碱酰胺、顺铂联合治疗晚期非小细胞肺癌108例  

Mitomycin, vindesine and cisplatin combination therapy in the treatment of advanced non small cell lung cancer : a report of 108 cases

作　　者：张湘茹[1] 孙燕[1] 冯奉仪[1] 徐兵河[1] 张弘纲[1] 周立强[1] 李青[1] 张频[1] 何小慧[1] 王宏羽[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院,北京100021

出　　处：《中华肿瘤杂志》1999年第3期220-223,共4页Chinese Journal of Oncology

摘　　要：目的　观察丝裂霉素（ＭＭＣ） 、长春花碱酰胺（ＶＤＳ） 、顺铂（ＤＤＰ） 联合化疗治疗晚期非小细胞肺癌的疗效。方法　治疗非小细胞肺癌患者１０８ 例。病理类型以腺癌（７４ 例） 和鳞癌（２３ 例） 为主。初治７８ 例，复治３０ 例。结果　完全缓解１ 例，部分缓解３６ 例，总有效率３４．３％ 。其中初治者有效率４１．０ ％ ，复治者有效率１６．７ ％ （ Ｐ＝０ ．０１６９） 。鳞癌有效率３０．４％ ，腺癌有效率３２．４％ 。淋巴结转移、肺原发肿瘤、肺内转移、肝转移和骨转移的有效率依次为４３．１％ 、３７ ．６％ 、３２ ．４ ％ 、２５．０ ％ 和０。中位缓解期３ 个月，中位生存期７ 个月。该方案的剂量限制性毒性为骨髓抑制，Ⅲ、Ⅳ度白细胞下降率为４１ ．７％ ，Ⅲ、Ⅳ度血小板下降率为６．５ ％ ，Ⅲ、Ⅳ度恶心呕吐发生率为２１．３％ 。结论　ＭＭＣ、ＶＤＳ、ＤＤＰ联合治疗非小细胞肺癌，有效率较高，其毒性患者可以耐受。Objective To evaluate the results of combination chemotherapy with mitomycin (MMC), vindesine (VDS) and cisplatin (DDP) in patients with advanced non small cell lung cancer (NSCLC). Methods A total of 108 patients with advanced NSCLC was enrolled in this study. Adenocarcinoma (74 cases) and squamous cell carcinoma (23 cases) were the most common type of malignancy. Thirty patients received prior chemotherapy while 78 did not. Results Complete response was observed in 1 patient and partial response in 36 patients with an overall response rate (RR) of 34.3%. The RR was significantly higher in the previously untreated patients (41.0%) and than that in the pretreated patients ( P =0.0169). The RR did not significantly differ between patients with squamous-cell carcinoma (30.4%) and adenocarcinoma (32.4%). That of patients with metastases to the lymph nodes, to the other parts of lung, liver and bone was 43.1%, 32.4%, 25.0% and 0, respectively. The median response duration was 3 months and the median survival period was 7 months. The dose limiting toxicity was neutropenia, which was in grade III and IV in 41.7% of the treated patients. Grade III and IV thrombocytopenia was observed in 6.5% and grade III and IV nausea and vomiting in 21.3% of the treated patients. Conclusion A higher response rate is attainable in patients with advanced NSCLC treated by MMC, VDS and DDP with tolerable toxicity.

关 键 词：肺肿瘤 非小细胞肺癌 药物疗法 丝裂霉素 VDS 

分 类 号：R734.205[医药卫生—肿瘤]