胸腺瘤合并淋巴细胞增高1例报告并文献复习  

Study on progressive cell lymphocytosis associated with thymoma,1 case report and review literature

作　　者：朱艳哲[1] 孙国平[1] 

机构地区：[1]安徽医科大学第一附属医院肿瘤内科,安徽合肥230022

出　　处：《罕少疾病杂志》2010年第5期39-41,44,共4页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨探讨胸腺瘤的病理类型、治疗及预后,以及胸腺瘤合并T淋巴细胞增高的可能机制。方法报告1例胸腺瘤合并T淋巴细胞增高患者的诊断、治疗与转归,用流式细胞术测定了患者外周血及骨髓中的T细胞亚群,并进行相关文献复习。结果患者外周血及骨髓T淋巴细胞CD3+、CD8+值绝对增高,CD4+值下降,使CD4+/CD8+比值明显降低。结论胸腺瘤合并T淋巴细胞增高并不多见,这种现象的原因尚不清楚,可能与胸腺瘤导致免疫系统紊乱有关。胸腺瘤是一种对化疗敏感的肿瘤,以DDP为主的联合化疗方案作为进展期或复发、转移的恶性胸腺瘤的首选治疗手段。Objective To evaluate the clinicopathologic features, treatment and prognosis of thymoma, and to explore the the immune status and possible mechanisms of progressive T-cell lymphocytosis assiociated with thymoma. Methods We describe a new case of a progressive T-cell lymphocytosis assiociated with thymoma, determined periphery blood and Bone marrow T- lymphocyte subsets by flow cytometer as well as review literatures about it. Results The percentage of CD3 ＋T and CD8 ＋T cells were increased significantly in the patient, while the percentage of CD4 ＋ cells decreased significantly and the ratio of CD4 ＋T / CD8 ＋ T cell decreased significantly, what is more ,the number of lymphocytosis decreased significantly after chemotherapy for invasive thymoma. Conclution T- cell lymphocytosis is a condition rarely associated with malignant thymomas. The etiology of this unusual phenomenon remains obscure and may reflect the perturbation of systemic immunoregulation that accompanies thymic neoplasia. Thymomas are sensitive to chemotherapy.The efficiency of the combination treatment with DDP in thymoma was most prominent, which has the specific effect on the adanced or recurrence and metastasis of malignant thymoma.

关 键 词：胸腺瘤 病理类型 T淋巴细胞亚型 治疗 

分 类 号：R73[医药卫生—肿瘤]