胃癌组织中nm23基因蛋白和D2-40的表达及其临床意义  

Expression and Clinical Significance of D2-40 and nm23 Gene Protein in Gastric Carcinoma

作　　者：刘艳[1] 金延安[1] 刘俐敏[2] 

机构地区：[1]咸宁学院临床医学院诊断学教研室,湖北咸宁437100 [2]武汉科技大学医学院病理学教研室

出　　处：《咸宁学院学报（医学版）》2010年第5期389-391,共3页Journal of Xianning Univarsity(medical Sciences)

摘　　要：目的探讨nm23基因蛋白、D2-40的表达与胃癌淋巴管生成及侵袭转移的关系。方法采用免疫组织化学SP法对63例人胃癌组织中nm23基因、D2-40的表达情况进行分析。结果 nm23在胃癌中的表达低于正常胃黏膜组织,胃癌伴有淋巴结转移的表达低于无淋巴结转移的表达（P〈0.05）,与胃癌的侵袭转移倾向呈负相关（P〈0.05）;D2-40在胃癌中的表达明显高于正常胃黏膜组织,在Ⅲ~Ⅳ期胃癌显著高于Ⅰ期胃癌（P〈0.05）,伴淋巴结转移组明显高于无转移组（P〈0.05）,与胃癌的侵袭转移倾向呈正相关（P〈0.05）;胃癌中D2-40及nm23基因表达之间呈负相关（P〈0.05）。结论 nm23基因与D2-40的表达在胃癌淋巴转移中起重要作用,对预测胃癌的淋巴转移、判断预后及制定个体化综合治疗方案有一定的临床价值。Objective To study the relationship between the expression of D2-40 and nm23 gene protein and development and lymphangiogenesis in primary gastric carcinoma. Methods The expression of D2-40 and nm23 were examined by immunohistochemical SP technique in 63 gastric cancer.Results The nm23 positive expression was lower in stage Ⅲ~ Ⅳ of gastric cancer and gastric cancer with lymph node metastasis than that in normal gastric mucosa（P0.05）,and the tendency to invasion and metastasis of gastric cancer was negatively correlated with the expression of nm23（P0.05）.The D2-40 expression in gastric cancer was significantly higher than that in normal gastric mucosa.The D2-40 expression in stage Ⅲ~Ⅳ was significantly higher than stageⅠof gastric cancer（P0.05）,and with lymph node metastasis group was significantly higher than those without metastasis（P0.05）,The tendency to invasion and metastasis of gastric cancer was positively correlated with the expression of D2-40.There was negative correlation between the expression of D2-40 and the expression of nm23 in gastric cancer（P0 01）.Conclusion nm23 and D2-40 expression play an important role in lymph node metastasis of gastric cancer.

关 键 词：胃癌 D2-40 NM23基因 肿瘤转移 

分 类 号：R735.2[医药卫生—肿瘤]