绿茶素(TP-91)抗肿瘤作用的实验研究  

An Experimental Approach of the Anticancer Activity of Luchasu (TP91) Against Mice Transplantable Tumor

作　　者：吴永方[1] 韩志红[1] 徐国华 刘晓康 罗仁峰[1] 朱秀华 陈琼霞[1] 

机构地区：[1]武汉职工医学院

出　　处：《肿瘤防治研究》1999年第3期161-163,共3页Cancer Research on Prevention and Treatment

基　　金：武汉市科委资助

摘　　要：目的：研究绿茶素对肿瘤的预防和辅助治疗作用。方法：采用我院从湖北绿茶提取的绿茶素（ＴＰ９１）进行了多项指标综合观察的抗肿瘤实验。瘤株为小鼠Ｓ１８０，Ｈｅｌａ细胞和ＥＡＣ。结果：（１）ＴＰ９１具明显抗癌作用，对Ｓ１８０的抑瘤率达４３６％，体外试验对Ｈｅｌａ细胞和ＥＡＣ细胞均有抑制作用，药物作用２小时后癌细胞死亡率分别为９３％和４５％；（２）给药后血液高凝状态缓解、ｃＡＭＰ升高、ＳＯＤ活性增强，外周血Ｔ淋巴细胞百分率上升、以及肿瘤间质肥大细胞数增多；（３）检出ＴＰ９１含有硒、锗等２０种元素。This paper presents our recent results from a multiparameter observation of the anticancer activity of Luchasu (TP91) against mice tumor systems.TP91 was isolated from Chinese green tea.NIH mice were transplanted with S180 subcutaneously,and randomly divided into two groups,viz.,Luchasu (TP91) group and control group.Dosage of TP91 was 150 mg/kg/day,oral administration for seven days.control group received N.S. only.The results showed that Luchasu (TP91) possessed tumor suppressive effect.The inhibition rate for mice S180 was 436%.Luchasu (TP91) also inhibited growth of cultured Hela cells as well as EAC cells,as in vitro studies showed.Laboratory tests demonstrated that Luchasu (TP91) reduced blood coagulability,increased cAMP and SOD levels,and increased numbers of peripheral Tlymphocytes and stromal mast cells.Chemically,Luchasu (TP91) is a compound mainly contains EGCG and trace elements such as selenium and germinium.In the paper,mechanisms of action were discussed.It is of the authors opinion that Luchasu (TP91) is promising in chemoprevention and adjuvant therapy for human cancer.Further study is worth continuing.

关 键 词：绿茶素 肿瘤 预防 治疗 实验研究 

分 类 号：R73－36[医药卫生—肿瘤] R730.1[医药卫生—临床医学]