肾上腺皮质肿瘤增殖活性检测及预后意义  

The Proliferative Activity Detection in Adrenocortical Neoplasms and Their Clinical Significance

作　　者：阎晓初[1] 柳风轩[1] 贺光友[1] 

机构地区：[1]第三军医大学西南医院病理科

出　　处：《肿瘤防治研究》1999年第3期190-192,共3页Cancer Research on Prevention and Treatment

摘　　要：目的：探讨细胞增殖活性检测对肾上腺皮质肿瘤的诊断价值和预后。方法：采用ＤＮＡ含量测定、ＡｇＮＯＲ和ＰＣＮＡ染色对正常肾上腺皮质、皮质增生、腺瘤和癌进行细胞增殖活性检测。结果：正常肾上腺与皮质增生ＤＮＡ含量、ＡｇＮＯＲ计数、ＰＣＮＡ指数均值相接近（Ｐ＞００５），ＤＮＡ倍体主要呈二倍体。腺瘤较增生组相比三种指标均值相差显著（Ｐ＜００１）。The cell proliferative activity of normal,hyperplasia,adenoma and carcinoma in adrenal cortex were detected by using DNA cytophotometry,AgNOR and PCNA staining.The results showed:the average value of DNA contents,AgNOR counts and PCNA LI were no difference between normal and hyperplasia in adrenal cortex( P>0 05) .Their DNA ploidy presented mainly diploid.Between adenomas and hyperplasia,3 kinds of average value were significant difference( P<0 01 ).The DNA ploidy of adenomas were often diploid and euploid,their AgNOR counts and PCNA LI were small and prognosis were better.In carcinomas,3 kinds of average value remarkably increased( P<0 01) .The DNA ploidy presented non euploid(3 cases)and aneuploid(5 cases),the AgNOR counts and PCNA LI of the latter increased,their prognosis were poor.These indicated that cell proliferative activity detection have diagnosis and prognosis value in adrenocortical neoplasms.

关 键 词：肾上腺皮质肿瘤 细胞增殖活性 预后 诊断 

分 类 号：R736.6[医药卫生—肿瘤]