CA50、CEA、Cyfra21-1和SCC在肺癌患者中的表达及其临床意义  

The expression of CA50,CEA,Cyfra21-1 and SCC in lung cancer patients and its significance

作　　者：王莉[1] 贾志凌[1] 刘畅[1] 韩春红[1] 柴丽娜[1] 于忠和[1] 

机构地区：[1]北京军区总医院肿瘤科,北京100700

出　　处：《临床肺科杂志》2010年第12期1693-1694,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨血清肿瘤标志物CA50、CEA、Cyfra21-1和SCC在肺癌诊断中的价值。方法采用电化学发光法检测260例肺癌患者、65例肺良性病变患者及117例健康体检者血清CA50、CEA、Cyfra21-1和SCC的含量。结果肺癌患者CA50、CEA、Cyfra21-1和SCC在肺癌患者中的阳性率分别为46.9%、66.5%、57.7%和58.1%,显著高于肺部良性病变患者和健康对照组(P<0.05)。CA50、CEA、Cyfra21-1和SCC小细胞肺癌患者较非小细胞肺癌患者表达水平低。CA50和CEA在肺腺癌高表达;而Cyfra21-1在肺鳞癌高表达。结论血清CA50、CEA、Cyfra21-1和SCC检测对于肺癌诊断敏感性和特异性强,并有助于判断病理类型。Objective To study the diagnostic value of serum CA50,CEA,Cyfra21-1 and SCC detection in patients with lung cancer.Methods To detect serum CA50,CEA,Cyfra21-1 and SCC in 260 patients with lung cancer,65 patients with benign pulmonary diseases and 117 healthy persons by electrochemiluminescence method.Results The positive rate of CA50,CEA,Cyfra21-1 and SCC in patients with lung cancer was 46.9%,66.5%,57.7% and 58.1% respectively,significantly higher than the patients with benign pulmonary diseases and healthy persons（P 0.05）.The concentration of CA50,CEA,Cyfra21-1 and SCC in small cell lung cancer was lower than in non-small cell lung cancer.High level of CA50 and CEA was observed in adenocarcinoma,otherwise high level of Cyfra21-1 was observed squamous carcinoma.Conclusions Detection of serum CA50,CEA,Cyfra21-1 and SCC was sensitive and specific in lung cancer diagnosis,and was helpful to estimation of histologic types.

关 键 词：CA50 CEA CYFRA21-1 SCC 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]