肾病综合征患者弥漫性血管内凝血监测及血清Ig测定的临床意义  

Clinical Significance of Disseminated Intravascular Coagulation Monitoring and Serum Ig Determination in Nephrotic Syndrome Patients

作　　者：吴映娥[1] 陈勇生[1] 周佩芳[2] 杨也如[1] 卢冰贤[1] 

机构地区：[1]汕头大学医学院第一附属医院检验科,广东汕头515041 [2]汕头大学医学院第一附属医院风湿皮肤科,广东汕头515041

出　　处：《汕头大学医学院学报》2010年第3期168-170,共3页Journal of Shantou University Medical College

基　　金：汕头市重点科技项目资助(汕府科[2009]70号)

摘　　要：目的:探讨肾病综合征(NS)患者弥漫性血管内凝血(DIC)相关指标及血清Ig的变化及临床意义。方法:检测96例NS患者和31例正常人的DIC相关指标:凝血酶原时间、PT-INR、纤维蛋白原(Fib)、D-二聚体(D-dimer)、纤维蛋白降解产物(FDP)及血清Ig(IgA、IgM、IgG)浓度,根据病人对糖皮质激素(泼尼松)的反应,比较激素敏感型肾病综合征(SSNS,56例),激素抵抗型肾病综合征(SRNS,40例)与对照组之间的差别。结果:SSNS及SRNS组血浆Fib、D-dimer、FDP及IgM水平均明显高于对照组(P<0.01),IgG明显低于对照组(P<0.01)。SRNS组血浆Fib、D-dimer、FDP及IgM水平均明显高于SSNS组(P<0.01),IgG低于SSNS组(P<0.05)。结论:NS患者存在高凝血状态及体液免疫功能紊乱。Objective： To investigate the indexes of disseminated intravaseular coagulation（ DIC） and changes of serum Ig in nephrotie syndrome （NS） patients. Methods： The prothrombin time, PT-INR, fibrinogen （Fib）, D-dimer, fibrin degradation produet（FDP）and serum IgA, IgM, IgG in 96 NS patients（divided into SSNS（56 eases）and SRNS（40 eases）groups aeeording to the reaction of glueoeortieoid（prednisone））and 31 eontrol people were detected. Results： The values of Fib, D-dimer, FDP and IgM in the NS group were significantly higher than those in the eontrol group（ P 〈 0.01 ）. IgG was significantly lower than that in the eontrol group（ P 〈 0.01）. The values of Fib, D-dimer, FDP and IgM in the SRNS group were significantly higher than those in the SSNS group（ P 〈 0.01）, IgG was significant lower than that in the SSNS group（P 〈 0.05）. Conclusion： NS patients may be easy to get the DIC complication and remain the humoral hnmunofunetion.

关 键 词：肾病综合征 免疫球蛋白 弥漫性血管内凝血 

分 类 号：R363.27[医药卫生—病理学]