北虫草提取物促进运动性疲劳血生化指标恢复的实验研究  

Experimental Study on the Promoting Motion Fatigue Recover of the Cordyceps Militaris Extract on the Chemical Indicators in Blood of Human

作　　者：邢安辉[1] 王洪军[1] 谷凤文[1] 于宁[1] 王立强[1] 张锐 李春燕[3] 

机构地区：[1]中国人民解放军沈阳军区联勤部疾病预防控制中心,辽宁沈阳110034 [2]辽宁富丽华集团股份有限公司,辽宁沈阳110034 [3]沈阳中天生物工程有限公司,辽宁沈阳110016

出　　处：《时珍国医国药》2010年第10期2481-2483,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家"863"高技术研究发展计划基金项目资助(No.2002AA2Z3208)

摘　　要：目的通过检测血清睾酮、皮质醇、血乳酸和尿素氮含量的变化,评价北虫草提取物促进机体运动性疲劳恢复的生物学作用。方法以人体为研究对象,每个实验分2组,对照组和给药试验组,根据性别又分为男和女两组,男性48人,女性35人。血清睾酮、皮质醇含量测定采用放射免疫分析法,血乳酸和尿素氮含量测定分别采用乳酸分析仪与二乙酰-肟检测法。结果男性血清睾酮含量实验组(863.54±231.57)明显高于对照组(681.02±157.12)fmol/L,皮质醇含量实验组(20.20±2.66)低于对照组(26.38±6.42)nmol/L,差异有显著性(P<0.01)。女性血清皮质醇含量实验组(21.04±3.71)低于对照组(26.84±5.06)nmol/L,差异有显著性(P<0.05)。男性血乳酸和尿素氮含量实验组为(0.93±0.23)和(10.27±1.89)mmol/L,明显低于对照组(1.88±0.33)和(14.77±1.21)mmol/L,尿素氮差异有显著性(P<0.05)。结论北虫草提取物具有预防疲劳促进机体运动性疲劳恢复的作用。Objective To study the effects of Cordyceps militaris extract on the promoting motion fatigue recover on human by determining serum testosterone,cortisol,lactic acid and urea nitrogen contents. Methods Separately forty-eight man and thirty-five women were divided into two groups,including matched group and administration experimental drug group. Serum testoster-one and cortisol contents were determined by radioimmunoassay kit（ RIA kit） . Lactic acid and urea nitrogen contents were determined by YSI1500 Lacte Analyzers and Diacetyl Monoxime method. Results Serum testosterone and cortisol content in blood experimental drug group were（ 863. 54 ± 231. 57） fmol/L and （ 20. 20 ± 2. 66） nmol/L,（ 680. 02 ± 157. 12） fmol/L and （ 26. 38 ± 6. 42） nmol/L in male of matched group. Serum testosterone content in experimental drug group was obviously than that of matched group ,cortisol content was lower than that of matched group,and there was statistical significance （ P 0. 01） between the drug groups. The levels of serum testostenme experimental group and watched group were（ 21. 04 ± 3. 71） nmol/L,and（ 26. 84 ± 5. 06） nmol/L in female respectively,cortisol content was lower than that of matched group,and there was statistical significance （ P 0. 05） as compared with matched group. The contents of lacic aevle and area lltrogea in experimental drug group and watches group were（ 0. 93 ± 0. 23） and（ 10. 27 ± 1. 89） mmol/L,（ 1. 88 ± 0. 33） and（ 14. 77 ± 1. 21） mmol/L in male respectively,lactic acid and urea nitrogen was obviously lower than those of matched group,and there was statistical significance （ P 0. 05） compared with matched group. Conclusion The Cordyceps Militaris extract has anti-fatigue effect and bioactivity of promoting motion fatigue recover in human.

关 键 词：北虫草 运动性疲劳 放射免疫 

分 类 号：R285.5[医药卫生—中药学] R872.7[医药卫生—中医学]