褪黑素治疗脑损伤儿童睡眠障碍的疗效观察  

Effective observation of melatonin on treating sleep disorders in neurodevelopmental disorder children

作　　者：吴至凤[1] 张雨平[1] 赵雪晴[1] 廖伟[1] 

机构地区：[1]第三军医大学新桥医院儿科,重庆400037

出　　处：《重庆医学》2010年第21期2913-2914,共2页Chongqing medicine

摘　　要：目的探讨外源性褪黑素应用于脑损伤患儿睡眠障碍的效果。方法所有病例于每晚临睡前30 min服用3 mg褪黑素,若1周无效,增加至每晚6 mg,若2周无效,增加至每晚9 mg。采用儿童睡眠习惯问卷（the children′s sleep habits question-aire,CSHQ）观察治疗前后各睡眠指标的变化。结果治疗2~3周后睡眠抵触较前改善,睡眠潜伏期较前缩短,夜醒次数较前减少,CSHQ总分较前降低,治疗前后比较,差异有统计学意义（P〈0.05）。结论褪黑素治疗脑损伤儿童睡眠障碍具有改善部分睡眠指标的疗效。Objective To investigate the effect of melatonin on treating sleep disorders in children with neurodevelopmental disorders.Methods All patients took 3mg melatonin at half an hour before going to sleep every night,if one week′s melatonin was observed to be invalid,then increased 3mg per night until getting the effective dose.The Children′s Sleep Habits Questionaire（CSHQ） was used to evaluate the effect before and after treatment.Results After 4 weeks,bedtime resistance was inproved,sleep latency was shorter,night wakings was reduced,the CSHQ′s total score was lower than before,with statistical difference comparing with before（P〈0.05）.Conclusion Melatonin is effective to treat sleep disorders in neurodevelopmental disorder children and improve some sleep indicators.

关 键 词：睡眠障碍 褪黑素 脑损伤 儿童 

分 类 号：R740[医药卫生—神经病学与精神病学]