脉冲染料激光治疗微静脉畸形的自身对照研究  

Self-Comparative Study of Pulse Dye Laser for the Venular Malformation

作　　者：王维[1,2] 林晓曦[1] 马刚[1] 李伟[1] 胡晓洁[1] 金云波[1] 陈辉[1] 杨川[1] 王炜[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,上海市200011 [2]上海市皮肤病性病医院

出　　处：《组织工程与重建外科杂志》2010年第5期272-275,共4页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：目的通过应用第一代和第二代脉冲染料激光(Pulse dye laser,PDL)治疗微静脉畸形(Venular malformation,即Port wine stain,PWS)自身对照的前瞻性研究,比较两代PDL治疗PWS的差异。方法 50名未曾接受任何治疗的PWS患者,病灶中选取两处区域,分别使用第一代和第二代PDL进行治疗。第一代PDL:585 nm(Cynosure,USA),光斑5 mm,脉宽0.45 ms,能量密度5～6.5 J/cm2,无冷却装置;第二代PDL:595 nm(Candela V-beam,USA),光斑5 mm,脉宽1.5～3 ms,能量密度11～12.5 J/cm2,DCD(动态冷却系统)冷却剂喷射时间20 ms(间隔20 ms)。术后6周比较第一代和第二代PDL的疗效。结果两代PDL治疗不同类型及不同部位PWS的疗效均无统计学差异,但第一代PDL术后出现暂时性色素减退比例高于第二代PDL。结论第一代和第二代PDL治疗PWS的疗效无显著差异,但使用了皮肤冷却系统的第二代PDL可以有效减少副反应的发生。Objective To investigate the therapeutic results of first and second generation PDL for port wine stain（PWS） and compare its difference.Methods Fifty patients（range 17-59 years） were treated with first and second generation of PDL.First generation of PDL was featured wit wave length 585 nm,5 mm spot size,pulse width 0.45 ms at frequency 5-6.5 J/cm2.Second generation of PDL was featured with wave length 595 nm,5 mm spot size,pulse width 1.5-3 ms at fluences 11-12.5 J/cm2,DCD was used dynamic cooling duration 20 ms,delay 20 ms.Results Based on chi-squared analysis,there was no statistically significant differences between first and second generation of PDL.Conclusion There was no significant difference of clinical outcome between the first and second generation PDL for the treatment of PWS.Cryogen spray cool equipment of second generation of PDL can improve the safety of PDL effectually.

关 键 词：微静脉畸形 脉冲染料激光 自身对照 

分 类 号：R730.57[医药卫生—肿瘤]