曼月乐环在治疗子宫腺肌病及避孕中的临床疗效观察  

Clinical evaluation of levonorgestrel-releasing intrauterine system for treatment of adenomyosis of uterus and contraception

作　　者：刘海燕[1] 杨先华[1] 宋丽[1] 

机构地区：[1]昌吉州人民医院妇科,新疆昌吉831100

出　　处：《新疆医科大学学报》2010年第8期961-963,共3页Journal of Xinjiang Medical University

摘　　要：目的探讨左炔诺酮宫内释放系统(LNG-IUS;商品名:曼月乐)治疗子宫腺肌病及避孕中的临床疗效。方法选择83例患者,其中子宫腺肌病导致中、重度痛经及/或月经过多的62例以及月经过多及/或普通节育器避孕失败、要求避孕患者21例。均于月经周期的第4～7天放置LNG-INS,分别在放置前及放置后3、6、12个月观察自身痛经程度、月经量、血红蛋白、子宫体积及避孕效果。结果放置左炔诺酮T形宫内节育器后,子宫腺肌病患者痛经评分:放置前为(90±11)分,放置后3个月为(12±7)分,痛经明显减轻,差异有统计学意义(P<0.01)。月经量评分效果,在放置后3、6、12个月的月经量降低分别为治疗前的(29±12)%、(17±4)%、(9±4)%,与放置前比较差异有统计学意义(P<0.05)。放置LNG-IUS后子宫体积明显减小,差异有统计学意义(P<0.05)。42例贫血患者放置LNG-IUS3个月后血红蛋白升至(126±8)g/L,放置LNG-INS期间避孕有效率达100%。结论宫内放置左炔诺酮T形宫内节育器为子宫腺肌病患者提供了一个安全、有效的保守治疗方法,明显减轻患者的临床症状及体征,提高患者生活质量,同时也不失为一个良好的避孕工具。Objective To investigate the clinical evaluation of Levonorgestrel-releasing intrauterine system for treatment of Adenomyosis and contraception.Methods All the patients,eighty-three of them with Adenomyosis,62 cases with moderate or severe dysmenorrhea associated with adenomyosis,21 cases with menstrual blood loss or need contraception,were inserted LNG-INS into their uterine cavity on the 4~7 th day of menstral cycle.The dysmenorrhoea scores,mensural blood loss,hemoglobin,uterine volume and contraception were recorded before and after 3,6 and 12 months insertion respectively.Results After insertion of Mirena,the dysmenorrhea scores,before and in 3 months,were 90±11 versus 12±7;and the menserual blood loss,before and 3,6,12 months,following the insertion,were （29±10）%,（17±4）%,（9±4）%;the dysmenorrhea scores and menserual blood loss reduced significantly from those before treatment （P0.01,P0.05）.The uterine volume decreased also （P0.05）.42 patients′ hemoglobin level had increased to normal.And the effective rate was 100% in contraception.Conclusion LNG-INS is an effective and safe method for controlling the symptoms of adenomyosis.Mirena inserting inside uterine cavity can significantly alleviate the clinical symptoms of adenomyosis.Moreover,it can improve the patients living quality,and is quite promising method in the contraception.

关 键 词：曼月乐 子宫腺肌病 避孕 

分 类 号：R731.9[医药卫生—肿瘤] R711.74[医药卫生—临床医学]