The association between the metabolites of intestinal flora and diabetes mellitus  

作　　者：WANG Ye WANG Chang-hui YU Xin-lan LI Ge LIU Jing-bao GAO Bing MAO Xin-min LI Lin-lin 

机构地区：[1]Department of Pharmacology, Xinjiang Medical University, Urumqi 830011, China [2]Lanzhou General Military District Hospital,Urumqi 830011, China） [3]Xinjiang Laboratory for the Control of Foods and Drugs, Urumqi 830011, China）

出　　处：《新疆医科大学学报》2010年第9期1063-1066,共4页Journal of Xinjiang Medical University

基　　金：National natural science foundation project(NO.30760288)

摘　　要：Objective To contrast and analyze the difference of metabolites of intestinal flora between patients with type 2diabetes and normal blood glucose human in Xinjiang Uygur and Kazak.Methods Uygur fecal samples and Kazak fecal samples were collected,and short-chain fatty acids(SCFA)were extracted by water from feces,then the content of SCFA in fecal samples was analyzed by gas-chromatography mass-spectrometry(GC-MS).Results Both Uygurs and Kazaks,in their feces,the content of SCFA in the feces showed significantly decreased in patients with type 2diabetes,and a significant negative linear correlation was shown between the fasting plasma glucose and the concentration of SCFA in the fecal samples.But,there was no statistical differences between uygurs and kazaks,in not only normal blood glucose group,but also type 2 diabetes group.Conclusion The feces of patients with type 2diabetes has an decreased concentration of SCFA.Between Uygurs and Kazaks,the metabolic changes of intestinal flora was similar in patients with type 2diabetes.Objective To contrast and analyze the difference of metabolites of intestinal flora between patients with type 2diabetes and normal blood glucose human in Xinjiang Uygur and Kazak.Methods Uygur fecal samples and Kazak fecal samples were collected,and short-chain fatty acids（SCFA）were extracted by water from feces,then the content of SCFA in fecal samples was analyzed by gas-chromatography mass-spectrometry（GC-MS）.Results Both Uygurs and Kazaks,in their feces,the content of SCFA in the feces showed significantly decreased in patients with type 2diabetes,and a significant negative linear correlation was shown between the fasting plasma glucose and the concentration of SCFA in the fecal samples.But,there was no statistical differences between uygurs and kazaks,in not only normal blood glucose group,but also type 2 diabetes group.Conclusion The feces of patients with type 2diabetes has an decreased concentration of SCFA.Between Uygurs and Kazaks,the metabolic changes of intestinal flora was similar in patients with type 2diabetes.

关 键 词：type 2diabetes intestinal flora SCFA GC-MS 

分 类 号：R587.1[医药卫生—内分泌]