吉西他滨与顺铂联合化疗治疗晚期膀胱癌的疗效和不良反应  

Curative effect and adverse reactions of gemcitabine combined with cisplatin in treatment of late bladder cancer

作　　者：毕兴[1] 陈鹏[1] 舒博[1] 

机构地区：[1]新疆医科大学附属肿瘤医院泌尿外科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2010年第9期1086-1088,共3页Journal of Xinjiang Medical University

摘　　要：目的探讨吉西他滨与顺铂联合化疗治疗晚期膀胱癌的疗效和不良反应。方法 28例晚期膀胱癌患者行吉西他滨800～1000mg/m2静脉滴注30min,第1、8、15天;顺铂25mg/m2静脉滴注,第1～3天。28d为1个周期,2～3个周期后评价疗效和不良反应。结果 1例患者化疗第1天出现急性肾功能衰竭而终止化疗,其余27例共行86个周期。其中CR3例(11.1%),PR10例(37.0%),SD9例(33.3%),PD5例(18.5%),总有效率为48.1%。中位缓解期为23周。主要毒副反应为骨髓抑制、恶心、呕吐、乏力、便秘。骨髓抑制表现为白细胞降低、血小板降低、贫血。肝功能损害、脱发、过敏反应均较轻。结论吉西他滨与顺铂联合化疗是治疗晚期膀胱癌的有效方法,并且毒副反应相对较轻。Objective To evaluate the effect and adverse reactions of gemcitabine combined with cisplatin for the treatment of later bladder cancer.Methods 28patients with later bladder cancer were treated with gemcitabine（800～1 000mg/m2）that was drip intravenous intracavitary in 30minute on d1,d8and d8,cisplatin（25mg/m2）that was infused on d1～d3.The regimen was repeated every 28d.Curative effects and adverse reactions were evaluated after 2or 3cycles.Results Because of acute renal failure on the first day of chemotherapy,one patient terminated chemotherapy.The other 27patients finished 86cycles in all.Of those 3of 27were CR（11.1%）,10of 27were PR（37.0%）,9of 27were SD（33.3%）,5of 27were PD（18.5%）.The overall response rate was 48.1%.The median time to progression was 23weeks.The main adverse reactions were hematologic toxicity,nausea,vomit,tired and constipation,the manifestations of hematologic toxicity were white blood cell,blood platelet and hemoglobin all decresed.The other adverse reactions were liver toxicity,alopecia and hypersensitiveness,but all of these reactions were light.Conclusion gemcitabine combined with cisplatin is effective method in treatment the later bladder cancer and the toxicity is light.

关 键 词：膀胱癌 吉西他滨 顺铂 

分 类 号：R737.14[医药卫生—肿瘤]