磺酰胺基取代的咪唑化合物对荷H22肝癌小鼠的放射增敏效应  

RADIOSENSITION OF THE MOUSE H22 HEPATOMA BY SUIFONAMIDE IMIDAZOLE

作　　者：严敏芬[1] 金一尊[1] 童顺高 许立明[1] 

机构地区：[1]上海医科大学放射医学研究所

出　　处：《辐射研究与辐射工艺学报》1999年第2期115-118,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金

摘　　要：研究全新放射增敏剂－磺酰胺基取代的咪唑化合物（化学名：１－取代－４－磺酰胺基咪唑，简称ＩＶｂ。）对荷Ｈ２２肝癌小鼠的放射增敏作用。实验结果表明：与空白对照组相比，照射前腹腔注射Ｉｖｂ０．５８～０．１４ｇ／ｋｇ后，肿瘤体积变小，肿瘤相对增长速度明显减小，肿瘤抑制率增加，肿瘤生长延迟天数也有一定程度增加，表现出ＩＶｂ对肿瘤生长的抑制作用，其中以照射前注射０．２９ｇ／ｋｇ剂量组最明显（肿瘤抑制率为４８％）。而单纯照射组、单纯用药（高、中、低剂量）组和空白对照组相比，则没有明显的抑制肿瘤作用。与单纯照射组相比，照射加用药０．２９ｇ／ｋｇ，肿瘤相对增长速度明显减小，肿瘤抑制率增加，肿瘤生长延迟天数也有一定程度增加。由此可见，ＩＶｂ对Ｈ２２肝癌具有放射增敏作用。The purpose of the present study was to investigate whether the sulfonamide-imidazole(IVb) had radiosensitization effects on H22 tumor. Mice with H22 epatoma were randonized into eight groups:control; radiation alone; radiation+ip 0.58g/kg IVb; radiation+ip 0.29g/kg IVb; radiation+ip 0.14g/kg IVb; ip 0.5g/kg IVb alone; ip 0.29g/kg IVb alone; ip 0.14g/kg IVb alone. IVb was diluted with normal saline and administered to the mice before irradiation. The dose of radiation is 10Gy. Each group was treated mentioned above . The volume of mice's tumors was measured every two days . We calculated relative tumor growth rates ,tumor inhibition rates and days of tumor growth delay .At the doses of 0.58g/kg, 0.29g/kg and 0.14g/kg IVb with γ-ray radiation, the relative growth rates decreased and the tumor inhibition rates, the days of tumor growth delay increased, respectively. Among the three doses, the inhibition effects on tumors was most significant at the dose of 0.29g/kg. There was no effect when IVb was adimin istered alone. The results indicated that IVb has some radiosensitization effects on H22 hepatoma in vivo.

关 键 词：咪唑化合物 IVb 放射增敏剂 肿瘤生长 肝癌 

分 类 号：R730.55[医药卫生—肿瘤] R735.7[医药卫生—临床医学]