低剂量辐射抑制辐射诱发小鼠胸腺淋巴瘤的免疫学机制  

IMMUNOLOGIC MECHANISM OF THE SUPPRESSIVE EFFECT OF LOW DOSE RADIATION ON THYMIC LYMPHOMA INDUCED BY RADIATION

作　　者：李秀娟[1] 杨英[1] 李修义[1] 刘树铮[1] 

机构地区：[1]白求恩医科大学卫生部放射生物重点实验室

出　　处：《辐射研究与辐射工艺学报》1999年第2期125-128,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金

摘　　要：为探讨低剂量辐射对高剂量辐射诱发小鼠胸腺淋巴瘤抑制作用的免疫学机制，采用４次１．７５ＧｙＸ射线全身照射Ｃ５７ＢＬ／６Ｊ小鼠诱发胸腺淋巴瘤模型，检测不同辐射剂量照后１个月小鼠脾脏ＮＫ细胞毒活性及其ＩＬ－２和γ－ＩＦＮ分泌活性，腹腔巨噬细胞吞噬功能及其ＴＮＦ－α分泌活性。结果显示，每次１．７５Ｇｙ照射前１２ｈ接受７５ｍＧｙ照射小鼠，上述免疫功能均比单纯１．７５Ｇｙ照射组增强，且接近假照射组小鼠。提示低剂量辐射抑制高剂量辐射诱发胸腺淋巴瘤可能与低剂量辐射诱导的适应性反应，减轻高剂量辐射对机体免疫功能的损伤有关。To study immunologic mechanism of the suppressive effect of low dose radiation(LDR) on thymic lymphoma(TL) induced by high dose radiation(HDR). We adopted the model that C57BL/6J mice were administered whole body irradiation with 1.75Gy X-rays one time every week for 4 weeks to induce TL. It was examined that splenic NK cytotoxic activity, IL-2 and γ-IFN secretion activity, peritoneal macrophagic phagocytosis and its TNF-α secretion activity in mice with different dose 1 month after irradiation. The results showed that all the immunologic functions mentioned above in mice given 75mGy 12h before 1.75Gy every time were higher than that in mice given only 1.75Gy, and approached to the sham-irradiation mice. It suggested that the suppressive effect of LDR on TL induced by HDR may be related to the adaptive response induced by LDR and decreasing immunological functions damage caused by HDR.

关 键 词：低剂量 辐射 高剂量 胸腺淋巴瘤 免疫功能 小鼠 

分 类 号：R736.3[医药卫生—肿瘤] R730.55[医药卫生—临床医学]