原因不明习惯性流产患者抗子宫内膜抗体和肿瘤坏死因子α的测定  

Determination of serum antiendometrial antibody and tumor necrosis factor α in women with habitual abortion of unknown etiology

作　　者：贾莉婷[1,2] 李培育[1,2] 任芬若[1,2] 韩书心[1,2] 刘东峰 

机构地区：[1]河南医科大学第三附属医院 [2]河南医科大学第二附属医院

出　　处：《中国免疫学杂志》1999年第4期189-190,共2页Chinese Journal of Immunology

基　　金：河南省科委资助项目

摘　　要：目的：探讨抗子宫内膜抗体（ＥｍＡｂ）和肿瘤坏死因子α（ＴＮＦα）与原因不明习惯性流产（ＨＡ）的关系。方法：应用酶免和放免法对５９例原因不明ＨＡ（研究组）和２０名正常对照的血清ＥｍＡｂ和ＴＮＦα含量进行测定，其中研究组分为Ａ组（每次流产均小于１２ｗ，３１例）和Ｂ组（至少有一次流产大于１２ｗ，２８例）。结果：原因不明ＨＡ的ＥｍＡｂ阳性率为５０８５％，ＴＮＦα水平为０５８５±０３０９μｇ／Ｌ，而正常对照未见ＥｍＡｂ阳性（Ｐ＜０００５），其ＴＮＦα为０３３４±０２６５μｇ／Ｌ（Ｐ＜０００５）；Ａ组ＥｍＡｂ阳性率及ＴＮＦα水平均明显高于Ｂ组（Ｐ＜０００５，Ｐ＜００２）。结论：ＥｍＡｂ和ＴＮＦα在ＨＡ发病中可能起着重要作用，尤其对早期流产患者。Objective:To study the relationships between habitual abortion(HA) of unknown etiology and antiendometrial antibody(EmAb),tumor necrosis factor α (TNFα).Methods:Serum EmAb and TNFα were measured by ELISA and RIA in women with HA of unknown etiology( n =59,study group)and normal control( n =20).The study group was further divided into two subgroups(every aboltion<12 w,group A, n =31;one or more abortions>12 w,group B, n =28).Results:The total positive rate of EmAb in HA group was 50.85%(30/59),which was significantly higher than that of control group( P <0.005).The level of TNFα in HA group was 0.585±0.309 μg/L,which was significantly higher than that of control group( P <0.005).Compared EmAb positive rate and level of TNFα,group A were higher than group B( P <0.005, P <0.02).Conclusion:The results suggested EmAb and TNFα play an important role in the process of HA,especially early pregnancy loss.

关 键 词：习惯性流产 抗子宫内膜抗体 肿瘤坏死因子 

分 类 号：R714.210.3[医药卫生—妇产科学]