活性炭固载酸性催化剂合成水杨酸异丙酯  

Synthesis of isopropyl salicylicate using acid catalyst supported on granular active carbon

作　　者：李继忠[1] 覃岩[1] 郑博[1] 

机构地区：[1]延安大学化学化工学院,陕西延安716000

出　　处：《工业催化》2010年第10期63-65,共3页Industrial Catalysis

摘　　要：以水杨酸和异丙醇为原料,采用颗粒状活性炭固载对甲苯磺酸作催化剂合成水杨酸异丙酯,考察影响反应因素,结果表明,酯化反应最佳条件为:n(水杨酸)∶n(异丙醇)=1∶3.0,催化剂用量1.5 g,为反应物总质量的4.6%,反应时间3.0 h,带水剂甲苯用量8 mL,此条件下,水杨酸异丙酯收率可达94.45%。Isopropyl salicylicate was synthesized using salicylic acid and i-propanol as raw materials and p-toluene sulphonic acid supported on granule activated carbon as the catalyst. The influencing factors of the reaction were investigated. Experimental results indicated that isopropyl salicylicate yield of 94.45% was attained under the optimum condition of esterification reaction as follows ： n （ salicylic acid） ： n （ isopropanol） = 1： 3.0, reaction time of 3.0 h, catalyst dosage 4.6% of total mass of the reactants, water carrying agent 8 mL.

关 键 词：有机合成化学 水杨酸异丙酯 活性炭 对甲苯磺酸 酯化反应 

分 类 号：O643.36[理学—物理化学] TQ225.24[理学—化学]