纤维素酶分子结构和功能研究进展  

Progress in Structure Function Studies of Cellulases.

作　　者：阎伯旭[1] 齐飞[1] 张颖舒[1] 高培基[1] 

机构地区：[1]山东大学微生物技术国家重点实验室

出　　处：《生物化学与生物物理进展》1999年第3期233-237,共5页Progress In Biochemistry and Biophysics

基　　金：国家教委博士点基金

摘　　要：概述了近１０年来利用结构生物学和蛋白质工程技术在纤维素酶分子结构和功能方面研究的进展，包括：酶分子结构域的拆分、催化域和纤维素结合结构域的结构和功能的研究，纤维素酶的分子折叠．The recent advance in structure function studies of cellulases by structural biology and protein engineering is reviewed.The seperation of structural domains and the structure function studies of catalytic domains and cellulose binding domains are included.The research prospects of cellulases are forecasted.According to the sequence similarity of amino acid, cellulase and hemicellulase can be divided in to nine families, and in five families there are some enzymes that three dimension structure have been resolved.Here, three dimension structure of some cellulase and xylanase were compared, and the relationship between its molecular folding and catalytic mechanism were also analyzed.

关 键 词：纤维素酶 催化结构域 分子折叠 活性位点 功能 

分 类 号：Q556.2[生物学—生物化学] Q946.562