黏附分子CD44v3和血管内皮生长因子C在胃癌组织中的表达及其意义  

Expression and clinical significance of CD44v3 and VEGF-C in gastric cancers

作　　者：王林[1] 夏忠胜[2] 曾韵洁[1] 彭挺生[3] 吕军[2] 李海刚[1] 

机构地区：[1]中山大学附属第二医院病理科,广东省广州510120 [2]中山大学附属第二医院内科,广东省广州510120 [3]中山大学附属第一医院病理科

出　　处：《中国基层医药》2010年第20期2740-2742,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨胃癌组织中黏附分子CD44v3和血管内皮生长因子C（VEGF-C）的表达及其临床意义.方法 应用免疫组织化学SP法检测92例胃癌组织中CD44v3和VEGF-C的表达情况.结果 胃癌组织CD44v3阳性表达率为27.2%,在不同性别、部位、浸润深度、WHO分型、Lauren分型、有无远处器官转移组之间,差异均无统计学意义（均P＞0.05）,而与淋巴结转移状况、组织分化密切相关,差异有统计学意义（均P＜0.05）;胃癌组织中VEGF-C阳性表达率为48.9%,在不同性别、部位、分化程度、浸润深度、WHO分型、有无远处器官转移组之间,差异均无统计学意义（均P＞0.05）,而与Lauren分型、淋巴结转移密切相关,差异均有统计学意义（均P＜0.05）.Cox-Regression分析显示对生存率有影响的因子只有淋巴结转移情况（P=0.015）.结论 检测44v3和VEGF-C表达对预测胃癌病程进展和胃癌转移潜能有一定价值,但对患者的生存率并无影响;两者在促进胃癌的转移方面并无协同作用.Objective To investigate the expression of CD44v3 and VEGF-C in human gastric cancers and the clinical significance. Methods The expression of CD44v3 and VEGF-C was detected by immunohistochemistry SP method in 92 gastric cancer tissues. Results Positive immunohistochemical stain for CD44v3 was identified in 27.2% of gastric cancer tissues. There was no correlation found among the expression of CD44v3 with sex, location,depth of invasion, WHO type, Lauren type as well as distant metastasis （all P ＞ 0. 05 ）. The expression of CD44v3 was positively correlated with lymph node metastasis and tumor differentiation（ all P ＜ 0. 05 ）. Positive immunohistochemical stain for VEGF-C was identified in 48.9% of gastric cancer tissues. There was no correlation found among the expression of VEGF-C with sex,location, tumor differentiation, depth of invasion, WHO type, as well as distant metastasis （ all P ＞ 0. 05 ）. The expression of VEGF-C was positively correlated with lymph node metastasis and Lauren type （ all P ＜0. 05）. Cox-Regression reflected that only the lymphatic metastasis situation correlated with the life ratio（ P =0. 015）. Conclusion The expression of CD44v3 and VEGF-C could suggest the progression and metastatic potential value of gastric cancer,but didnt correlate with the life ratio. There was no cooperation between CD44v3 and VEGF-C in promoting gastric cancer metastasis.

关 键 词：胃肿瘤 细胞黏附分子 抗原 CD44 血管内皮生长因子C 

分 类 号：R735[医药卫生—肿瘤]