52例自身免疫性肝炎临床及病理学特征分析  

Clinical and Pathological Characteristics of 52 Cases With Autoimmune Hepatitis

作　　者：梁颖莹[1] 梁宾勇[1] 齐俊英[1] 杨道锋[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2010年第5期237-239,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨自身免疫性肝炎(AIH)的临床和病理学特征,以提高对AIH的诊治水平。方法:回顾分析52例AIH患者的临床资料。结果:AIH的临床表现无特异性,以血IgG、γ-球蛋白升高为主,伴不同程度的自身抗体升高,肝活检呈慢性肝炎表现,小剂量泼尼松联合硫唑嘌呤治疗可使92.7%的患者病情缓解。结论:AIH的临床表现、血清生化学改变、自身抗体及组织病理学等方面均无特异性,临床医师应提高认知水平,警惕AIH的漏诊、误诊,早日采取激素联合硫唑嘌呤治疗可显著改善预后。Objctive：To explore the clinical and pathological characteristics of autoimmune hepatitis （AIH） in order to improve the level of diagnosis and treatment of AIH.Methods：Clinical data of 52 patients with AIH were retrospectively analyzed.Results：The manifestations of AIH were non-specific,but it showed elevated levels of IgG,γ-globulin and autoantibodies,liver biopsy specimens mainly showed changes of chronic hepatitis,92.7% of the patients got remission after receiving low dose of prednisone combined with Azathioprine.Conclusions：The manifestations,serum biochemical changes,autoantibodies and phathological changes of AIH were non-specific.AIH is a chronic hepatitis of unkown etiology that can progress to cirrhosis,physicians should promote the recognition of AIH,which is impotant for the early diagnosis and treatment.

关 键 词：自身免疫性肝炎 原发性胆汁性肝硬化 重叠综合征 

分 类 号：R575.1[医药卫生—消化系统]