绒毛滋养细胞染色体分析及临床应用  

Analysis method of chorionic trophocyte chromosomes and its clinical application

作　　者：姜淑芳[1] 卢彦平[1] 赵玉梅[1] 徐滨[1] 付玉荣[1] 姚元庆[1] 

机构地区：[1]解放军总医院妇产科,北京100853

出　　处：《军医进修学院学报》2010年第11期1081-1082,共2页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的建立绒毛滋养细胞染色体核型分析方法,用于探讨早孕期自然流产的病因。方法通过体外细胞培养获取较多的绒毛滋养细胞中期分裂相,制备染色体片进行核型分析,观察早孕期流产绒毛滋养细胞染色体畸形的发生率。结果成功建立了滋养细胞染色体核型分析方法,58.3%(21/36)的早孕期自然流产患者滋养细胞染色体异常。结论开展流产绒毛滋养细胞染色体核型分析,对于明确早孕期自然流产病因具有重要的临床价值。Objective To establish the analysis method of chorionic trophocyte chromosomes and its application in study of early spontaneous abortion etiology. Methods Division metaphase of chorionic trophocytes was obtained by in vitro culture of chorionic trophocytes. Chromosome sections were prepared for analysis of their karyotypes. Incidence of chromosomal aberration in chorionic trophocytes at early spontaneous abortion was observed. Results The analysis method of chorionic trophocyte karyotype was successfully established. Chromosomal aberration was found in 58.3% of pregnant women with early spontaneous abortion. Conclusion Analysis of chorionic trophocyte karyotype is of important value in study of early spontaneous abortion etiology.

关 键 词：绒毛膜绒毛 滋养层 染色体 流产 自然 

分 类 号：R714.21[医药卫生—妇产科学]