马立克氏病病毒Meq基因缺失株的保护性免疫作用  

Comparison of Marek's Disease Virus Meq-deletion Mutants for Their Protective Immunity

作　　者：崔治中[1] 苏帅[1] 赵鹏[1] 李延鹏[1] 丁家波[2] 孙爱军[1] 

机构地区：[1]山东农业大学动物医学院,山东泰安271018 [2]中国兽医药品监察所,北京100081

出　　处：《中国兽药杂志》2010年第10期2-5,共4页Chinese Journal of Veterinary Drug

摘　　要：马立克氏病病毒(MDV)的致病性一直在不断增强中,甚至已出现了能抵抗CV1988/Rispens疫苗的特超强株。本实验室用BAC克隆技术构建了MDV中国野毒株的Meq基因缺失株,显示出在抗马立克氏病方面具有与美国Meq基因缺失株同样有效的保护性免疫效果,而且其自身没有明显的免疫抑制作用。对美国和中国的两个MDV的Meg基因缺失株的优缺点做了比较。The pathogenicity of Marek＇s disease viruses（MDV） is being continuously increased,even some very virulent plus MDV strains resistant to CVI988/Rispens emerged.A Meq-deletion mutant from Chinese field strain GX0101 with BAC clone technique was constructed in our lab,it also demonstrated better protective immunity than CVI988.In this paper,both Meq-deletion mutants from America and China were compared for their protective immunity and other biological characteristics.

关 键 词：马立克氏病病毒 Meq基因缺失株 保护性免疫 

分 类 号：S852.659.1[农业科学—基础兽医学]