α-玉米赤霉醇对去卵巢大鼠骨代谢生化指标的影响  

作　　者：程炜[1,2] 李少春[1] 段斐[1] 崔娜[1] 高文[1] 

机构地区：[1]河北大学基础医学院 [2]河北省保定市第一医院,河北保定071000

出　　处：《中国民族民间医药》2010年第20期6-6,9,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：河北省卫生厅基金资助项目(07128);河北大学预研基金项目(2007JY04)

摘　　要：目的:应用去卵巢大鼠建立绝经后骨质疏松症模型,观察α-ZAL对绝经后骨质疏松症的骨代谢生化指标的影响。方法:40只6月龄雌性SD大鼠随机分为4组:假手术组(Sham)、模型组(OVX)、雌二醇组(OVX+E2)、α-ZAL(OVX+α-ZAL)。术后三周灌胃给予假手术组和模型组生理盐水1mL/100g·d,雌二醇组给予戊酸雌二醇1mg/kg/d,α-ZAL组给予α-ZAL1mg/kg/d。12周后处死动物,分离血清,测定ALP、BGP、TRACP和ICTP等血清骨代谢生化指标。结果:E2组和α-ZAL组TRACP和ICTP较模型显著降低。E2和α-ZAL能降低血清ALP和BGP浓度,但较假手术组升高。结论:α-ZAL对绝经后骨质疏松症模型动物具有与E2类似的调节骨代谢生化指标的作用,提示可能具有广阔的治疗绝经后骨质疏松症的应用前景。Objective：To examine the effect of the phytoestrogen α-zearalanol（α-ZAL）on bone metabolic marker in ovariectomized rats.Method：40 six-month old SD female rats were randomly divided into four groups：Sham group,control group（ovariectomized）,estrogen group（ovariectomized and fed estrogen）,α-zearalanol group（ovariectomized and fed ovariectomized and fed estrogen）.Three weeks post-surgery,the sham group and control group were treated daily by oral gavage with distilled water（1 ml/kg/day）,and the other two groups were fed with estradiol valerate（1 mg/kg/day）or α-zearalanol for 12 weeks.After treatment,serum TRCAP,ICTP,ALP and BGP were measured.Result：Serum ALP and BGP of estrogen group and α-zearalanol group were lower than control group.And α-zearalanol can decrease serumTRAP and ICTP levels.Conclusion：α-zearalanol can regulate bone metabolic marker,reduce the resorption of bone,and have preventive and therapeutic effect to postmenopausal osteoporosis in rats.

关 键 词：α-ZAL 去卵巢大鼠 绝经后骨质疏松症 骨代谢生化指标 

分 类 号：R-332[医药卫生]