β-纤维蛋白原-455G/A、-148C/T基因多态性与合并脑梗死的心房颤动的关系  

Relationship between β-fibrinogen gene - 455G/A,- 148C/T polymorphisms and atrial fibrillation with cerebral infarction

作　　者：崔国方[1] 孟竹[2] 修振顺[1] 何亚萍[1] 宋达琳[2] 康维强[2] 

机构地区：[1]青岛市海慈医院心内科,266033 [2]青岛市市立医院东院区干部特需一科,266071

出　　处：《国际脑血管病杂志》2010年第9期654-657,共4页International Journal of Cerebrovascular Diseases

摘　　要：目的 探讨β-纤维蛋白原（p-fibrinogen,β-Fg）-455G/A、-148C/T基因多态性与合并心房颤动（atrial fibrillation,AF）的脑梗死的关系.方法 应用聚合酶链反应-限制性片段长度多态性方法检测92例合并脑梗死的AF患者（合并脑梗死组）、80例单纯AF患者（单纯AF组）和98例健康者（健康对照组）-455G/A和-148C/T基因型.结果 合并脑梗死组和单纯AF组-455G/AA等位基因频率分别为0.304和0.344,显著高于健康对照组的0.179（P均＜0.05） 合并脑梗死组和单纯AF组-148C/TT等位基因频率分别为0.348和0.369,显著高于健康对照组的0.240（P均＜0.05）.结论 -455G/AA等位基因、-148C/TT等位基因与AF合并脑梗死和AF有关.Objective To investigate the relationship between β-fibrinogen （β-Fg） gene -455G/A,- 148C/T polymorphisms and atrial fibrillation （AF） with cerebral infarction.Methods Polymerase chain reaction-restriction fragment length polymorphism was used to detect the genotypes of -455G/A and -148C/T in 97 patients with AF with cerebral infarction （AF with cerebral infarction group）,80 patients with AF alone （AF group）,and 98 health subjects （healthy control group）.Results The A allele frequencies of -455G/A in the AF with cerebral infarction group and the AF group were 0.304 and 0.344 respectively.They were significantly higher than 0.179 in the healthy control group （all P〈0.05）.The T allele frequencies of - 148C/T in the AF with cerebral infarction group and the AF group were 0.348and 0.369,respectively.They were significant higher than 0.240 in the healthy control group （all P〈0.05）.Conclusions The A allele of -455G/A and the T allele of -148C/T were associated with AF with cerebral infarction and AF.

关 键 词：纤维蛋白原 多态现象 遗传 基因频率 基因型 脑梗死 心房颤动 

分 类 号：R743.3[医药卫生—神经病学与精神病学]