依托咪酯对普鲁卡因、丁卡因致惊厥半数有效量的影响  

The Influence of Etomidate on Convulsant ED50 Induced by Chlorprocaine and Ropivacaine in Mice

作　　者：郭根花[1,2] 蒋月明[1,2] 丁晓维[1,2] 张一肖[1,2] 王树桂[1,2] 马涛[1] 

机构地区：[1]徐州医学院麻醉药理学教研室,江苏徐州221002 [2]徐州医学院麻醉学院

出　　处：《航空航天医药》2010年第10期1784-1785,共2页Aerospace Medicine

基　　金：江苏省高校自然科学基础研究资助项目(项目编号:09KJB320019)

摘　　要：目的:观察依托咪酯对普鲁卡因、丁卡因致惊厥半数有效量的影响。方法:将64只小鼠随机分为4组(n=16),分别为普鲁卡因组、丁卡因组、依托咪酯+普鲁卡因组、依托咪酯+丁卡因组。实验小鼠均采用腹腔注射的给药方法,用序贯法测各组惊厥的半数有效量。结果:与普鲁卡因组比较,依托咪酯+普鲁卡因组致惊厥ED50显著提高(P<0.01);与丁卡因组比较,依托咪酯+丁卡因组致惊厥的半数有效量显著提高(P<0.01)。结论:预先给一定剂量的依托咪酯可以提高普鲁卡因或丁卡因致惊厥阈值,说明依托咪酯对局麻药引起的惊厥有一定的防治作用。Objective：To observe the influence of etomidate on convulsion ED50 （ 50%. effective dose ） induced by chlorprocaine and ropivacaine in mice. Methods：64 mice were randomly divided into four groups （n = 16 ） ： chlorprocaine group, ropivacaine group, etomidate ＋ chlorprocaine group, etomidate ＋ ropivacaine group. The mice were administrated by intraperitoneal injection （ ip ） and the convulsant ED50 was determined by sequential method. Results： Compared with chlorprocaine group, the convulsant EDs0 of etomidate ＋ chlorproeaine group was increased apparently （P 〈 0. 01 ） ; compared with ropivacaine group, the convulsant ED50 of etomidate ＋ ropivacaine group was increased significantly （ P 〈 0. 01 ）. Conclusions ： Pior to administration by some etomdiate can increase the convulsant threshold of chlorprocaine or ropivaeaine that is etomdiate can prevent the convulsant effects induced by local anesthetics to some extent.

关 键 词：依托咪酯 普鲁卡因 丁卡因 惊厥半数有效量 抗惊厥 

分 类 号：R-332[医药卫生]