江西地区宫颈癌及癌前病变组织DNA中HPV16型基因组相关序列的检测  

Detection of DNA sequence related to HPV 16 genome in cervical neoplasia in Jiangxi region

作　　者：郭韵玉 龚林 曾晓南 杨学志 邓水生[2] 林玉纯[3] 

机构地区：[1]江西省妇产医院 [2]江西省医学科学研究所 [3]中国医学科学院肿瘤研究所

出　　处：《实用肿瘤杂志》1990年第2期78-80,共3页Journal of Practical Oncology

摘　　要：日益增多的资料表明,人乳头瘤病毒(HPV)与人宫颈癌的发生、发展存在着颇为密切的关系。自应用核酸分子杂交技术,进行宫颈癌病毒病因的研究,已获很大的进展,尤其是在宫颈癌组织DNA中发现HPV16及18型基因组,为宫颈癌病毒病因的研究,提供了很有价值的线索。我省是宫颈癌高发区之一,早在1985年,我们参加了中国医科院肿瘤所组织的我国有关省市关于“宫颈癌发病与HPV感染关系”的协作研究,现将1985～1988年江西地区的宫颈湿疣、非典型增生、宫颈早期癌。The present paper reports the use of ^(32)F-dTTP-labelled HPV16 DNA as a probe to detect the DNA sequence related to HPV16 genome in 73 cases of invasive cervical cancer, 18 cases of early cervical cancer, 23 cases of dysplasia and 87 non-neoplastic cervical tissues as controls, the posi- tive rates being 75%, 71%, 65% and 3.4% respectively. The result has suggested that cervical neoplasia might be related to HPV infection, that the relation between the disease and HPV might become closer with the development of the lesion in the cervix. An important evidence has thus been provided at the molecular level for the prevention and blocking of the genesis and develop- ment of cervical neoplasia, as well as for its diagnosis and treatment.

关 键 词：宫颈癌 DNA HPV 16型 基因组 

分 类 号：R737.330.2[医药卫生—肿瘤]