抑郁症情绪加工过程中的脑功能连通性分析  

Brain Functional Connectivity in Depression During Emotion Processing

作　　者：魏玲[1] 李颖洁[1] 唐莺莹[2] 王继军[3] 

机构地区：[1]上海大学通信与信息工程学院,上海200072 [2]上海交通大学生命科学技术学院,上海200240 [3]上海交通大学精神卫生中心脑电影像室,上海200030

出　　处：《生物医学工程学杂志》2010年第5期961-967,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(60871090);国家高技术研究发展计划(863计划)项目资助(2008AA02Z412)

摘　　要：抑郁症患者的情绪认知障碍已经得到广泛地研究,但其生理机制目前尚不明确。以不同种族的多种情绪面孔作为视觉刺激,选取16名抑郁症患者和16名正常被试参与＂学习-判断＂认知任务,同步记录他们的头皮脑电信号。分析不同脑功能区域之间脑电信号的相关性,并利用重复测量方差分析方法对相干值进行了统计分析,结果发现：（1）抑郁症患者各频带额区的半球间相干值均低于正常人,表明额区半球间的连通性下降,额区不活跃导致了情绪认知能力削弱;（2）视觉刺激后1~200 ms范围内,脑电β活动的半球间相干值与情绪加工显著相关,而且负性情绪刺激时半球间的同步性较中性和正性情绪加强;（3）视觉刺激后401~600 ms范围内,δ和θ频带发现种族的主效应显著,本族面孔刺激时半球间的连通性较强。Cognitive and emotional dysfunction in depressed patients has been broadly researched.However,the physiological mechanism of the emotional impairment is still obscure.In this study,according to the ethical principles and the procedures of informed consent,we enrolled 16 depression patients and 16 normal subjects in a ＂learning-judgment＂ cognitive task.Emotional faces were chosen and used as the visual stimuli,while the subjects＇ scalp electroencephalographs（EEG） were recorded.We calculated the coherences of the event-related EEG signals between different functional brain regions and used the repeated measure analysis of variance（ANOVA） to analyze the coherences.The results revealed：（1）The depressed patients had a significantly lower inter-hemisphere coherence than did the normal controls at frontal sites across all EEG basic rhythms;（2） The inter-hemispheric coherence of EEG beta activity was significantly correlated with the emotional processing during 1-200ms after stimulus onset,and the synchronicity with the negative emotion stimulus was higher than that with neutral and positive stimuli;（3） The main effect of race was found at delta and theta bands at about 401-600ms after stimulus onset.Moreover,the connectivity of inter-hemisphere for own-race stimulus was stronger than that for other-race stimulus.

关 键 词：事件相关脑电 抑郁症 相干分析 情绪 种族 

分 类 号：R749.4[医药卫生—神经病学与精神病学]