普通型脆性部位与食管癌易感性的相关性  

Relationship between common sites and susceptibility in patients with esophageal cancer

作　　者：周宏远[1] 梁谋[1] 李世绩[1] 高秀坤[1] 陶德明 

机构地区：[1]华西医科大学肿瘤研究所 [2]四川盐亭县肿瘤防治研究所

出　　处：《实用肿瘤杂志》1990年第4期238-240,共3页Journal of Practical Oncology

基　　金：四川省卫生厅资助课题

摘　　要：自Yunis(1983)首次报告了染色体脆性部位与肿瘤细胞染色体重排相关以来,大量研究结果表明,某些肿瘤患者的脆性部位、肿瘤相关断裂点及癌基因位点这三者在人类基因组中具有定位的相关性。本文对四川盐亭县食管癌患者的一级亲属的染色体畸变率(CAR)及脆性部位进行了检测,着重对普通型脆性部位(Common fragile sites,c-fra)与食管癌易感性的相关性作了探讨。材料与方法一、研究对象 4个食管癌高发家族(即连续两代以上有两名患者的家族)的一级亲属(父母、兄弟、姐妹、子女)15例(男13例、女2例),年龄16～84岁;Chromosome common sites (c-fra) analysis has been conducted by using banding technique in 15 cases of first relatives of high incidence, 13 of first relatives of low incidence and 12 normal individuals. The results indicated that there was a highly significant difference (P<0.01)in CAR (11.95%), c-fra (6.05%) among the first relatives of high incidence and the low incidence (6.11%; 2.67%) and the normal individuals (7.38%; 2.62%). The common sites in the first relatives of high inci- dence were significantly interrelated with neoplasia-associated breakpoints and oncogene sites,and the common sites were the genetic basis of susceptibility with EC.

关 键 词：食道癌 染色体畸变率 脆性部位 

分 类 号：R735.102[医药卫生—肿瘤]